A polymeric prodrug of cisplatin based on pullulan for the targeted therapy against hepatocellular carcinoma.-论文-万方医学网

第一作者： Yan,Wang

第一单位： School of Pharmacy, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics) & Research Center of Basic Medical Science, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, PR China.

作者： Yan,Wang ^[1] ; Yuanyuan,Liu ^[2] ; Yang,Liu ^[2] ; Wen,Zhou ^[1] ; Hemei,Wang ^[1] ; Guoyun,Wan ^[1] ; Duxin,Sun ^[3] ; Ning,Zhang ^[4] ; Yinsong,Wang ^[5]

作者单位： School of Pharmacy, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics) & Research Center of Basic Medical Science, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, PR China. ^[1] School of Pharmacy, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics) & Research Center of Basic Medical Science, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, PR China; Cancer Institute and Hospital, Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Medical University, Huanhuxi Road, Hexi District, Tianjin 300060, PR China. ^[2] Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA. ^[3] School of Pharmacy, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics) & Research Center of Basic Medical Science, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, PR China; Cancer Institute and Hospital, Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Medical University, Huanhuxi Road, Hexi District, Tianjin 300060, PR China. Electronic address: zhangning@tijmu.edu.cn. ^[4] School of Pharmacy, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics) & Research Center of Basic Medical Science, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070, PR China. Electronic address: wangyinsong@tijmu.edu.cn. ^[5]

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);癌, 肝细胞(Carcinoma, Hepatocellular);细胞周期(Cell Cycle);细胞增殖(Cell Proliferation);细胞存活(Cell Survival);顺铂(Cisplatin);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);女(雌)性(Female);Hep G2细胞(Hep G2 Cells);人类(Humans);肝肿瘤(Liver Neoplasms);肝肿瘤, 实验性(Liver Neoplasms, Experimental);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);分子结构(Molecular Structure);聚合物(Polymers);药物前体(Prodrugs);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.ijpharm.2015.02.027

PMID 25681730

发布时间 2015-03-09

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A polymeric prodrug of cisplatin based on pullulan for the targeted therapy against hepatocellular carcinoma.

International journal of pharmaceutics

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International journal of pharmaceutics

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A polymeric prodrug of cisplatin based on pullulan for the targeted therapy against hepatocellular carcinoma.

International journal of pharmaceutics

相似文献

International journal of pharmaceutics

相关期刊

检索历史清除