Intracranial biodegradable silica-based nimodipine drug release implant for treating vasospasm in subarachnoid hemorrhage in an experimental healthy pig and dog model.

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第一作者： Janne,Koskimäki

第一单位： Faculty of Medicine, University of Turku, P.O. Box 52, Kiinamyllynkatu 4-8, 20520 Turku, Finland ; Department of Neurosurgery, Helsinki University Central Hospital, P.O. Box 266, Topeliuksenkatu 5, 00029 Helsinki, Finland.

作者： Janne,Koskimäki ^[1] ; Miikka,Tarkia ^[2] ; Tuula,Ahtola-Sätilä ^[3] ; Lasse,Saloranta ^[3] ; Outi,Simola ^[3] ; Ari-Pekka,Forsback ^[4] ; Aki,Laakso ^[5] ; Janek,Frantzén ^[6]

作者单位： Faculty of Medicine, University of Turku, P.O. Box 52, Kiinamyllynkatu 4-8, 20520 Turku, Finland ; Department of Neurosurgery, Helsinki University Central Hospital, P.O. Box 266, Topeliuksenkatu 5, 00029 Helsinki, Finland. ^[1] Turku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, Kiinamyllynkatu 4-8, 20521 Turku, Finland. ^[2] Chemistry and Safety Sciences, R&D, Orion Corporation, Orion Pharma, P.O. Box 65, Orionintie 1A, 02101 Espoo, Finland. ^[3] Delsitech Ltd., Itäinen Pitkäkatu 4B, 20520 Turku, Finland. ^[4] Department of Neurosurgery, Helsinki University Central Hospital, P.O. Box 266, Topeliuksenkatu 5, 00029 Helsinki, Finland. ^[5] Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital, P.O. Box 52, Hämeentie 11, 20521 Turku, Finland. ^[6]

主题词动物(Animals);迟效制剂(Delayed-Action Preparations);疾病模型, 动物(Disease Models, Animal);狗(Dogs);颅内动脉瘤(Intracranial Aneurysm);尼莫地平(Nimodipine);二氧化硅(Silicon Dioxide);蛛网膜下腔出血(Subarachnoid Hemorrhage);猪(Swine);血管舒张药(Vasodilator Agents);血管痉挛, 颅内(Vasospasm, Intracranial)

DOI 10.1155/2015/715752

PMID 25685803

发布时间 2018-11-13

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BioMed research international

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Intracranial biodegradable silica-based nimodipine drug release implant for treating vasospasm in subarachnoid hemorrhage in an experimental healthy pig and dog model.

BioMed research international

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BioMed research international

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Intracranial biodegradable silica-based nimodipine drug release implant for treating vasospasm in subarachnoid hemorrhage in an experimental healthy pig and dog model.

BioMed research international

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BioMed research international

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