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Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.

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第一作者： Hao,Zhang

第一单位： Metabolic Diseases Chemistry, Bristol-Myers Squibb Research and Development (R&D), Princeton, NJ 08543-5400, USA.

作者： Hao,Zhang ^[1] ; Charles Z,Ding ^[1] ; Zhi,Lai ^[1] ; Sean S,Chen ^[1] ; Pratik,Devasthale ^[1] ; Tim,Herpin ^[1] ; George,Morton ^[1] ; Fucheng,Qu ^[1] ; Denis,Ryono ^[1] ; Rebecca,Smirk ^[1] ; Wei,Wang ^[1] ; Shung,Wu ^[1] ; Xiang-Xang,Ye ^[1] ; Yi-Xin,Li ^[2] ; Atsu,Apedo ^[2] ; Dennis,Farrelly ^[3] ; Tao,Wang ^[4] ; Liqun,Gu ^[3] ; Nathan,Morgan ^[3] ; Neil,Flynn ^[3] ; Cuixia,Chu ^[3] ; Lori,Kunselman ^[3] ; Jonathan,Lippy ^[4] ; Kenneth,Locke ^[4] ; Kevin,O'Malley ^[4] ; Thomas,Harrity ^[3] ; Michael,Cap ^[3] ; Lisa,Zhang ^[5] ; Vinayak,Hosagrahara ^[5] ; Pathanjali,Kadiyala ^[5] ; Carrie,Xu ^[5] ; Arthur M,Doweyko ^[6] ; Robert,Zahler ^[1] ; Narayanan,Hariharan ^[3] ; Peter T W,Cheng ^[1]

作者单位： Metabolic Diseases Chemistry, Bristol-Myers Squibb Research and Development (R&D), Princeton, NJ 08543-5400, USA. ^[1] Discovery Analytical Sciences, Bristol-Myers Squibb R&D, Princeton, NJ 08543-5400, USA. ^[2] Metabolic Diseases Biology, Bristol-Myers Squibb R&D, Princeton, NJ 08543-5400, USA. ^[3] Lead Evaluation, Bristol-Myers Squibb R&D, Princeton, NJ 08543-5400, USA. ^[4] Metabolism and Pharmacokinetics, Bristol-Myers Squibb R&D, Princeton, NJ 08543-5400, USA. ^[5] Computer-Assisted Drug Design, Bristol-Myers Squibb R&D, Princeton, NJ 08543-5400, USA. ^[6]

关键词 Dual agonists Peroxisome Proliferator-Activated Receptor Pyrrolidine acid Type 2 diabetes