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Characterization of the 5-HT2C receptor agonist lorcaserin on efficacy and safety measures in a rat model of diet-induced obesity.

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第一作者： Guy A,Higgins

第一单位： InterVivo Solutions Inc. 120 Carlton St., Toronto, Ontario, Canada, M5A 4K2 ; Department of Pharmacology & Toxicology, University of Toronto Toronto, Ontario, Canada.

作者： Guy A,Higgins ^[1] ; Jill,Desnoyer ^[2] ; Annalise,Van Niekerk ^[2] ; Leo B,Silenieks ^[2] ; Winnie,Lau ^[2] ; Sandy,Thevarkunnel ^[2] ; Julia,Izhakova ^[2] ; Ines Am,DeLannoy ^[2] ; Paul J,Fletcher ^[3] ; Josepha,DeLay ^[4] ; Howard,Dobson ^[5]

作者单位： InterVivo Solutions Inc. 120 Carlton St., Toronto, Ontario, Canada, M5A 4K2 ; Department of Pharmacology & Toxicology, University of Toronto Toronto, Ontario, Canada. ^[1] InterVivo Solutions Inc. 120 Carlton St., Toronto, Ontario, Canada, M5A 4K2. ^[2] Section of Biopsychology, Clarke Division, Centre for Addiction and Mental Health 250 College St., Toronto, Ontario, Canada, M5T 1R8 ; Department of Psychiatry & Psychology, University of Toronto Toronto, Ontario, Canada. ^[3] Animal Health Laboratory, U. Guelph Guelph, Ontario, Canada. ^[4] InterVivo Solutions Inc. 120 Carlton St., Toronto, Ontario, Canada, M5A 4K2 ; CanCog Technologies Inc. 120 Carlton St., Toronto, Ontario, Canada, M5A 4K2 ; Department of Clinical Studies, University of Guelph Guelph, Ontario, Canada ; Department of Biomedical Physics, University of Western Ontario London, Ontario, Canada. ^[5]

关键词 Biomarkers echocardiography efficacy lorcaserin obesity safety valvulopathy

DOI 10.1002/prp2.84

PMID 25692009

发布时间 2018-11-13

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Characterization of the 5-HT2C receptor agonist lorcaserin on efficacy and safety measures in a rat model of diet-induced obesity.

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Characterization of the 5-HT2C receptor agonist lorcaserin on efficacy and safety measures in a rat model of diet-induced obesity.

Pharmacology research & perspectives

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