Effect of proton-pump inhibitors on the risk of lower gastrointestinal bleeding associated with NSAIDs, aspirin, clopidogrel, and warfarin.

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作者： Naoyoshi,Nagata ^[1] ; Ryota,Niikura ^[2] ; Tomonori,Aoki ^[2] ; Toshiyuki,Sakurai ^[2] ; Shiori,Moriyasu ^[2] ; Takuro,Shimbo ^[3] ; Katsunori,Sekine ^[2] ; Hidetaka,Okubo ^[2] ; Kazuhiro,Watanabe ^[2] ; Chizu,Yokoi ^[2] ; Mikio,Yanase ^[2] ; Junichi,Akiyama ^[2] ; Naomi,Uemura ^[4]

作者单位： Department of Gastroenterology and Hepatology, International Clinical Research Center, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan. nnagata_ncgm@yahoo.co.jp. ^[1] Department of Gastroenterology and Hepatology, International Clinical Research Center, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan. ^[2] Department of Clinical Research and Informatics, International Clinical Research Center, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan. ^[3] Department of Gastroenterology and Hepatology, Kohnodai Hospital, National Center for Global Health and Medicine, Chiba, Japan. ^[4]

关键词 Antisecretory drugs Drug–drug interaction Lower gastrointestinal tract hemorrhage