Dynamic heterogeneity of DNA methylation and hydroxymethylation in embryonic stem cell populations captured by single-cell 3D high-content analysis.

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作者： Jian,Tajbakhsh ^[1] ; Darko,Stefanovski ^[2] ; George,Tang ^[3] ; Kolja,Wawrowsky ^[4] ; Naiyou,Liu ^[5] ; Jeffrey H,Fair ^[5]

作者单位： Chromatin Biology Laboratory, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Translational Cytomics Group, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: tajbakhshj@cshs.org. ^[1] Translational Cytomics Group, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19348, USA. ^[2] Chromatin Biology Laboratory, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Translational Cytomics Group, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. ^[3] Translational Cytomics Group, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. ^[4] Department of Surgery and UF Health Comprehensive Transplant Center, University of Florida College of Medicine, Gainesville, FL 32608, USA. ^[5]

关键词 3D high-content analysis DNA methylation Epigenetic phenotyping Hydroxymethylcytosine Stem cell heterogeneity Super-resolution imaging