换一批ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells.
第一作者：
Jing-Hong,Chen
第一单位：
a State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Cancer Center; Sun Yat-sen University ; Guangzhou , China.
作者：
关键词
AKT/PKB, v-akt murine thymoma viral oncogene homologAMPK, protein kinase, AMP-activatedATG, autophagy-relatedATMATM, ATM serine/threonine kinaseBaf.A1, bafilomycin A1CASP3, caspase 3, apoptosis-related cysteine peptidaseCCND1, cyclin D1CDDP, cisplatinCENPC/CENP-C, centromere protein CCITED1/p300/CBP, Cbp/p300-interacting transactivator, with Glu/Asp-rich C-terminal domain, 1CSNK2/CK2, casein kinase 2DNA damageDSBs, DNA double-strand breaksGAPDH, glyceraldehyde-3-phosphate dehydrogenaseGFP, green fluorescent proteinGLTSCR2/PICT-1, glioma tumor suppressor candidate region gene 2GSK3B, glycogen synthase kinase 3 βGST, glutathione S-transferaseH2A histone familyH2AFXJUNMAP1LC3/LC3, microtubule-associated protein 1 light chain 3MTORC1, mechanistic target of rapamycin complex 1MVP, major vault proteinNC, normal controlNEDD4, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligasePAGE, polyacrylamide gel electrophoresisPARP, poly (ADP-ribose) polymerase 1PI3K, phosphoinositide 3-kinasePMSF, phenylmethanesulfonyl fluoridePPase, protein phosphatasePTENPTEN, phosphatase and tensin homologPtdIns(3, 4, 5)P3, phosphatidylinositol (3, 4, 5)-trisphosphateRAD51, RAD51 recombinaseRPS6KB/p70S6KSDS, sodium dodecyl sulfateSESN2, sestrin 2SQSTM1/p62, sequestosome 1TP53, tumor protein p53TPT, topotecanTUBA4A, tubulin, α, 4aWT, wild typeYFP, yellow fluorescent proteinautophagyjun proto-oncogenemember Xribosomal protein S6 kinase, 70kDasiRNA, small interfering RNAtopotecan
医学主题词
主动转运, 细胞核(Active Transport, Cell Nucleus);抗肿瘤药(Antineoplastic Agents);自噬(Autophagy);顺铂(Cisplatin);DNA损伤(DNA Damage);人类(Humans);PTEN磷酸水解酶(PTEN Phosphohydrolase);磷酰化(Phosphorylation);信号传导(Signal Transduction);拓扑异构酶I抑制剂(Topoisomerase I Inhibitors);托泊替坎(Topotecan);肿瘤抑制蛋白质类(Tumor Suppressor Proteins)
DOI
10.1080/15548627.2015.1009767
PMID
25701194
发布时间
2021-12-03
- 浏览44
Autophagy
239-52页
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