首页> Bioorganic & medicinal chemistry letters> Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility.

Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility.

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第一作者： Gitte Kobberøe,Mikkelsen

第一单位： Department of Discovery Chemistry & DMPK, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark. Electronic address: gmi@lundbeck.com.

作者： Gitte Kobberøe,Mikkelsen ^[1] ; Morten,Langgård ^[2] ; Tenna Juul,Schrøder ^[3] ; Mads,Kreilgaard ^[2] ; Erling B,Jørgensen ^[4] ; Guillaume,Brandt ^[5] ; Yann,Griffon ^[5] ; Ray,Boffey ^[5] ; Benny,Bang-Andersen ^[2]

作者单位： Department of Discovery Chemistry & DMPK, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark. Electronic address: gmi@lundbeck.com. ^[1] Department of Discovery Chemistry & DMPK, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark. ^[2] Department of Molecular Pharmacology, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark. ^[3] Biologics & Pharmaceutical Science Department, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark. ^[4] Argenta Discovery Ltd, 8-9 The Spire Green Centre, Harlow CM19 5TR, UK. ^[5]

关键词 Solubility hA(2A)