Pr1E11, a novel anti-TROP-2 antibody isolated by adenovirus-based antibody screening, recognizes a unique epitope.

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作者： Masahiro,Ikeda ^[1] ; Miki,Yamaguchi ^[2] ; Kazunori,Kato ^[3] ; Kiminori,Nakamura ^[4] ; Sagano,Shiina ^[5] ; Takako,Ichikawa-Ando ^[5] ; Hirofumi,Misaka ^[5] ; Kensuke,Myojo ^[6] ; Kazuyasu,Nakamura ^[5] ; Yoshiyuki,Sugimoto ^[5] ; Hirofumi,Hamada ^[7]

作者单位： Tokyo Research Park, Kyowa Hakko Kirin Co., Ltd., Machida-shi, Tokyo 194-8533, Japan. Electronic address: masahiro.ikeda@kyowa-kirin.co.jp. ^[1] Department of Molecular Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8556, Japan. ^[2] Department of Biomedical Engineering, Toyo University, Kawagoe, Saitama 350-8585, Japan. ^[3] Department of Cell Biological Science, Faculty of Advanced Life Science, Graduate School of Life Science, Hokkaido University, Sapporo, Hokkaido 001-0021, Japan. ^[4] Tokyo Research Park, Kyowa Hakko Kirin Co., Ltd., Machida-shi, Tokyo 194-8533, Japan. ^[5] Fuji Research Park, Kyowa Hakko Kirin Co., Ltd., Nagaizumi-cho, Sunto-gun, Shizuoka 441-8731, Japan. ^[6] Department of Molecular Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8556, Japan; Laboratory of Oncology, School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan. ^[7]

关键词 Antibody Epitope Internalization Modified adenovirus vector TROP-2