换一批
换一批BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy.
作者：
关键词
ABT-737ACTB, actin, βBAK1BAK1, BCL2-antagonist/killer 1BAXBAX, BCL2-associated X proteinBCL2BCL2, B-cell CLL/lymphoma 2BECN1 (Beclin 1)BECN1, Beclin 1, autophagy-relatedBaf A1, bafilomycin A1DKO, double-knockoutFBS, fetal bovine serumGAPDH, glyceraldehyde-3-phosphate dehydrogenaseHBSS, Hanks’ balanced salt solutionHRP, horseradish peroxidaseMAP1LC3/LC3, microtubule-associated protein 1 light chain 3MCL1, myeloid cell leukemia 1MEFs, mouse embryonic fibroblastsMTOR, mechanistic target of rapamycinPBS, phosphate-buffered salineSQSTM1, sequestosome 1STS, staurosporineWT, wild typeapoptosisautophagy
主题词
动物(Animals);细胞凋亡(Apoptosis);凋亡调节蛋白质类(Apoptosis Regulatory Proteins);自噬(Autophagy);联苯化合物(Biphenyl Compounds);细胞系, 肿瘤(Cell Line, Tumor);成纤维细胞(Fibroblasts);流式细胞术(Flow Cytometry);HCT116细胞(HCT116 Cells);人类(Humans);膜蛋白质类(Membrane Proteins);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);显微镜检查, 荧光(Microscopy, Fluorescence);硝基酚类(Nitrophenols);肽碎片(Peptide Fragments);哌嗪类(Piperazines);蛋白质结合(Protein Binding);原癌基因蛋白质类(Proto-Oncogene Proteins);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);磺胺类(Sulfonamides);bcl-2同源拮抗杀伤蛋白质(bcl-2 Homologous Antagonist-Killer Protein);bcl-2相关X蛋白质(bcl-2-Associated X Protein)
DOI
10.1080/15548627.2015.1017191
PMID
25715028
发布时间
2018-11-13
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Autophagy
452-9页
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