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首页> Molecular aspects of medicine> Development, growth and maintenance of β-cell mass: models are also part of the story.

Development, growth and maintenance of β-cell mass: models are also part of the story.

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作者： Anmar,Khadra ^[1] ; Santiago,Schnell ^[2]

作者单位： Department of Physiology, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada. ^[1] Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA; Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA; Brehm Center for Diabetes Research, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA. Electronic address: schnells@umich.edu. ^[2]

关键词 Islet cytoarchitecture Mathematical models Pancreatic islet development β-cell apoptosis β-cell function β-cell neogenesis β-cell proliferation

主题词细胞大小(Cell Size);糖尿病, 1型(Diabetes Mellitus, Type 1);糖尿病, 2型(Diabetes Mellitus, Type 2);基因调控网络(Gene Regulatory Networks);葡萄糖(Glucose);内环境稳定(Homeostasis);人类(Humans);胰岛素(Insulin);胰岛素分泌细胞(Insulin-Secreting Cells);模型, 生物学(Models, Biological);信号传导(Signal Transduction)

DOI 10.1016/j.mam.2015.01.005

PMID 25720614

发布时间 2018-11-13

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Molecular aspects of medicine

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