The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent.-论文-万方医学网

作者： Peter B,Sampson ; Yong,Liu ; Bryan,Forrest ; Graham,Cumming ; Sze-Wan,Li ; Narendra Kumar,Patel ; Louise,Edwards ; Radoslaw,Laufer ; Miklos,Feher ; Fuqiang,Ban ; Donald E,Awrey ; Guodong,Mao ; Olga,Plotnikova ; Richard,Hodgson ; Irina,Beletskaya ; Jacqueline M,Mason ; Xunyi,Luo ; Vincent,Nadeem ; Xin,Wei ; Reza,Kiarash ; Brian,Madeira ; Ping,Huang ; Tak W,Mak ; Guohua,Pan ; Henry W,Pauls

主题词投药, 口服(Administration, Oral);动物(Animals);抗肿瘤药(Antineoplastic Agents);生物利用度(Biological Availability);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);狗(Dogs);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物发现(Drug Discovery);女(雌)性(Female);HCT116细胞(HCT116 Cells);人类(Humans);吲唑类(Indazoles);吲哚类(Indoles);男(雄)性(Male);小鼠, 裸(Mice, Nude);小鼠, SCID(Mice, SCID);模型, 化学(Models, Chemical);分子结构(Molecular Structure);肿瘤(Neoplasms);蛋白激酶抑制剂(Protein Kinase Inhibitors);大鼠(Rats);构效关系(Structure-Activity Relationship);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

PMID 25723005

发布时间 2021-12-03

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The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent.

Journal of medicinal chemistry

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Journal of medicinal chemistry

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The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent.

Journal of medicinal chemistry

相似文献

Journal of medicinal chemistry

相关期刊

检索历史清除

The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent.