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Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

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第一作者: Colin S,Cooper
第一单位: Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, UK.;Department of Biological Sciences University of East Anglia, Norwich, UK.;Norwich Medical School, University of East Anglia, Norwich, UK.
作者: Colin S,Cooper [1] ; Rosalind,Eeles [2] ; David C,Wedge [3] ; Peter,Van Loo [4] ; Gunes,Gundem [3] ; Ludmil B,Alexandrov [3] ; Barbara,Kremeyer [3] ; Adam,Butler [3] ; Andrew G,Lynch [5] ; Niedzica,Camacho [6] ; Charlie E,Massie [7] ; Jonathan,Kay [7] ; Hayley J,Luxton [7] ; Sandra,Edwards [6] ; ZSofia,Kote-Jarai [6] ; Nening,Dennis [8] ; Sue,Merson [6] ; Daniel,Leongamornlert [6] ; Jorge,Zamora [3] ; Cathy,Corbishley [9] ; Sarah,Thomas [8] ; Serena,Nik-Zainal [3] ; Sarah,O'Meara [3] ; Lucy,Matthews [6] ; Jeremy,Clark [10] ; Rachel,Hurst [10] ; Richard,Mithen [11] ; Robert G,Bristow [12] ; Paul C,Boutros [13] ; Michael,Fraser [14] ; Susanna,Cooke [3] ; Keiran,Raine [3] ; David,Jones [3] ; Andrew,Menzies [3] ; Lucy,Stebbings [3] ; Jon,Hinton [3] ; Jon,Teague [3] ; Stuart,McLaren [3] ; Laura,Mudie [3] ; Claire,Hardy [3] ; Elizabeth,Anderson [3] ; Olivia,Joseph [3] ; Victoria,Goody [3] ; Ben,Robinson [3] ; Mark,Maddison [3] ; Stephen,Gamble [3] ; Christopher,Greenman [15] ; Dan,Berney [16] ; Steven,Hazell [8] ; Naomi,Livni [8] ; ICGC Prostate Group [8] ; Cyril,Fisher [8] ; Christopher,Ogden [8] ; Pardeep,Kumar [8] ; Alan,Thompson [8] ; Christopher,Woodhouse [8] ; David,Nicol [8] ; Erik,Mayer [8] ; Tim,Dudderidge [7] ; Nimish C,Shah [7] ; Vincent,Gnanapragasam [17] ; Thierry,Voet [3] ; Peter,Campbell [3] ; Andrew,Futreal [18] ; Douglas,Easton [19] ; Anne Y,Warren [20] ; Christopher S,Foster [3] ; Michael R,Stratton [7] ; Hayley C,Whitaker [3] ; Ultan,McDermott [21] ; Daniel S,Brewer [22] ; David E,Neal
作者单位: Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, UK.;Department of Biological Sciences University of East Anglia, Norwich, UK.;Norwich Medical School, University of East Anglia, Norwich, UK. [1] Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, UK.;Royal Marsden NHS Foundation Trust, London and Sutton, UK. [2] Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK. [3] Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.;Human Genome Laboratory, Department of Human Genetics, VIB and KU Leuven, Leuven, Belgium.;Cancer Research UK London Research Institute, London, UK. [4] Statistics and Computational Biology Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, UK. [5] Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, UK. [6] Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, UK. [7] Royal Marsden NHS Foundation Trust, London and Sutton, UK. [8] Department of Histopathology, St Georges Hospital, London, UK. [9] Norwich Medical School, University of East Anglia, Norwich, UK. [10] Institute of Food Research, Norwich Research Park, Norwich, UK. [11] Department of Medical Biophysics, University of Toronto, Toronto, Canada.;Department of Radiation Oncology, University of Toronto, Toronto, Canada.;Princess Margaret Cancer Centre-University Health Network, Toronto, Canada. [12] Department of Medical Biophysics, University of Toronto, Toronto, Canada.;Informatics and Bio-Computing, Ontario Institute for Cancer Research, Toronto, Canada.;Department Pharmacology & Toxicology, University of Toronto, Toronto, Canada. [13] Department of Radiation Oncology, University of Toronto, Toronto, Canada.;Princess Margaret Cancer Centre-University Health Network, Toronto, Canada. [14] School of Computing Sciences, University of East Anglia, Norwich, UK. [15] Department of Molecular Oncology, Barts Cancer Centre, Barts and the London School of Medicine and Dentistry, London, UK. [16] Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven, Belgium. [17] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. [18] Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. [19] University of Liverpool, Liverpool, UK.;HCA Pathology Laboratories, London, UK. [20] Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, UK.;Norwich Medical School, University of East Anglia, Norwich, UK.;The Genome Analysis Centre, Norwich, UK. [21] Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, UK.;Department of Surgical Oncology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. [22]
DOI 10.1038/ng.3221
PMID 25730763
发布时间 2025-05-29
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