All-trans-retinoic acid inhibits chondrogenesis of rat embryo hindlimb bud mesenchymal cells by downregulating p53 expression.
第一作者:
Tao-Gen,Zhang
第一单位:
Department of Orthopedics, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen, Guangdong 518000, P.R. China.
作者:
主题词
软骨蛋白聚糖类(Aggrecans);动物(Animals);软骨(Cartilage);细胞分化(Cell Differentiation);软骨发生(Chondrogenesis);胶原Ⅱ型(Collagen Type II);周期素依赖激酶抑制剂p21(Cyclin-Dependent Kinase Inhibitor p21);剂量效应关系, 药物(Dose-Response Relationship, Drug);胚胎, 哺乳动物(Embryo, Mammalian);基因表达调控, 发育期(Gene Expression Regulation, Developmental);后肢(Hindlimb);肢芽(Limb Buds);间质干细胞(Mesenchymal Stem Cells);蛋白质生物合成(Protein Biosynthesis);RNA, 信使(RNA, Messenger);大鼠(Rats);SOX9转录因子类(SOX9 Transcription Factor);信号传导(Signal Transduction);维甲酸(Tretinoin);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)
DOI
10.3892/mmr.2015.3423
PMID
25738595
发布时间
2018-12-02
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