Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis.

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作者： E Zeynep,Erson-Omay ^[1] ; Ahmet Okay,Çağlayan ^[1] ; Nikolaus,Schultz ^[1] ; Nils,Weinhold ^[1] ; S Bülent,Omay ^[1] ; Koray,Özduman ^[1] ; Yavuz,Köksal ^[1] ; Jie,Li ^[1] ; Akdes,Serin Harmancı ^[1] ; Victoria,Clark ^[1] ; Geneive,Carrión-Grant ^[1] ; Jacob,Baranoski ^[1] ; Caner,Çağlar ^[1] ; Tanyeri,Barak ^[1] ; Süleyman,Coşkun ^[1] ; Burçin,Baran ^[1] ; Doğan,Köse ^[1] ; Jia,Sun ^[1] ; Mehmet,Bakırcıoğlu ^[1] ; Jennifer,Moliterno Günel ^[1] ; M Necmettin,Pamir ^[1] ; Ketu,Mishra-Gorur ^[1] ; Kaya,Bilguvar ^[1] ; Katsuhito,Yasuno ^[1] ; Alexander,Vortmeyer ^[1] ; Anita J,Huttner ^[1] ; Chris,Sander ^[1] ; Murat,Günel ^[1]

作者单位： Department of Neurosurgery, Yale Program in Brain Tumor Research, Yale School of Medicine, New Haven, Connecticut (E.Z.E.-O., A.O.Ç., S.B.O., A.S.H., V.C., G.C.-G., J.B., C.Ç., T.B., S.C., B.B., M.B., J.M.G., K.M.-G., K.B., K.Y., M.G.); Department of Genetics, Yale School of Medicine, New Haven, Connecticut (K.B., M.G.); Computational Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York (N.S., N.W., C.S.); Department of Neurosurgery, Acıbadem University School of Medicine, Istanbul, Turkey (K.O., M.N.P.); Division of Hematology and Oncology, Faculty of Medicine, Department of Pediatrics, Selçuk University, Konya, Turkey (Y.K., D.K.); Department of Pathology, Yale School of Medicine, New Haven, Connecticut (J.L., J.S., A.V., A.J.H.). ^[1]

关键词 better prognosis germline MSH6 mutation glioblastoma polymerase epsilon ultramutated tumor