PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine.

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作者： Isabel Vieira de Assis,Lima ^[1] ; Alline Cristina,Campos ^[2] ; Aline Silva,Miranda ^[2] ; Érica Leandro Marciano,Vieira ^[2] ; Flávia,Amaral-Martins ^[1] ; Juliana Priscila,Vago ^[3] ; Rebeca Priscila de Melo,Santos ^[1] ; Lirlândia Pires,Sousa ^[3] ; Luciene Bruno,Vieira ^[1] ; Mauro Martins,Teixeira ^[4] ; Bernd L,Fiebich ^[5] ; Márcio Flávio Dutra,Moraes ^[6] ; Antonio Lucio,Teixeira ^[2] ; Antonio Carlos Pinheiro,de Oliveira ^[7]

作者单位： Department of Pharmacology, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, 31270-901, Belo Horizonte, Brazil. ^[1] Department of Internal Medicine, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, 31270-901, Belo Horizonte, Brazil. ^[2] Department of Clinical and Toxicological Analysis, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, 31270-901, Belo Horizonte, Brazil. ^[3] Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, 31270-901, Belo Horizonte, Brazil. ^[4] Department of Psychiatry, University of Freiburg Medical School, Hauptstr. 5, D-79104 Freiburg, Germany. ^[5] Department of Biophysics and Physiology, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, 31270-901, Belo Horizonte, Brazil. ^[6] Department of Pharmacology, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, 31270-901, Belo Horizonte, Brazil. Electronic address: antoniooliveira@icb.ufmg.br. ^[7]

关键词 Cytokines Glutamate Microglia Neurodegeneration Neurotrophins Phosphatidylinositol 3-kinase Pilocarpine Seizures