Pharmacokinetic-pharmacodynamic analysis to evaluate the effect of moxifloxacin on QT interval prolongation in healthy Korean male subjects.

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作者： Taegon,Hong ^[1] ; Seunghoon,Han ^[1] ; Jongtae,Lee ^[1] ; Sangil,Jeon ^[1] ; Gab-Jin,Park ^[1] ; Wan-Su,Park ^[1] ; Kyoung Soo,Lim ^[2] ; Jae-Yong,Chung ^[3] ; Kyung-Sang,Yu ^[2] ; Dong-Seok,Yim ^[1]

作者单位： Department of Pharmacology, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea ; PIPET (Pharmacometrics Institute for Practical Education and Training), the Catholic University of Korea, Seoul, Republic of Korea. ^[1] Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea. ^[2] Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Bundang Hospital, Seongnam, Republic of Korea. ^[3]

关键词 Emax model NONMEM PK-PD model thorough QT study

主题词成年人(Adult);心电描记术(Electrocardiography);荧光喹诺酮类(Fluoroquinolones);人类(Humans);男(雄)性(Male);韩国(Republic of Korea);青年人(Young Adult)

DOI 10.2147/DDDT.S79772

PMID 25750520

发布时间 2022-12-07

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Drug design, development and therapy

2015年9卷

1233-45页

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Pharmacokinetic-pharmacodynamic analysis to evaluate the effect of moxifloxacin on QT interval prolongation in healthy Korean male subjects.

Drug design, development and therapy

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Drug design, development and therapy

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Pharmacokinetic-pharmacodynamic analysis to evaluate the effect of moxifloxacin on QT interval prolongation in healthy Korean male subjects.

Drug design, development and therapy

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Drug design, development and therapy

相关期刊

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