The polycomb group protein L3MBTL1 represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells.

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作者： Fabiana,Perna ^[1] ; Ly P,Vu ^[2] ; Maria,Themeli ^[2] ; Sonja,Kriks ^[3] ; Ruben,Hoya-Arias ^[2] ; Raya,Khanin ^[4] ; Todd,Hricik ^[5] ; Jorge,Mansilla-Soto ^[2] ; Eirini P,Papapetrou ^[6] ; Ross L,Levine ^[5] ; Lorenz,Studer ^[3] ; Michel,Sadelain ^[2] ; Stephen D,Nimer ^[7]

作者单位： Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: pernaf@mskcc.org. ^[1] Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[2] Center for Stem Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[3] Bioinformatics Core, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[4] Human Oncology and Pathogenesis Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[5] Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[6] Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Electronic address: snimer@med.miami.edu. ^[7]

主题词细胞分化(Cell Differentiation);染色体蛋白质类, 非组蛋白(Chromosomal Proteins, Non-Histone);减量调节(Down-Regulation);红系前体细胞(Erythroid Precursor Cells);基因表达调控, 发育期(Gene Expression Regulation, Developmental);血细胞生成(Hematopoiesis);人类(Humans);免疫表型分型(Immunophenotyping);诱导多能干细胞(Induced Pluripotent Stem Cells);神经干细胞(Neural Stem Cells);多潜能干细胞(Pluripotent Stem Cells);阻遏蛋白质类(Repressor Proteins);Smad5蛋白质(Smad5 Protein);转录, 遗传(Transcription, Genetic);肿瘤抑制蛋白质类(Tumor Suppressor Proteins)

DOI 10.1016/j.stemcr.2015.02.003

PMID 25754204

发布时间 2020-12-09

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Stem cell reports

2015年4卷4期

658-69页

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The polycomb group protein L3MBTL1 represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells.

Stem cell reports

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Stem cell reports

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The polycomb group protein L3MBTL1 represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells.

Stem cell reports

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Stem cell reports

相关期刊

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