换一批Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis.
第一作者：
Hongjin,Lu
第一单位：
Division of Infection and Pathway Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
作者：
医学主题词
转录激活因子3(Activating Transcription Factor 3);动物(Animals);骨髓细胞(Bone Marrow Cells);细胞, 培养的(Cells, Cultured);羟基胆甾醇类(Hydroxycholesterols);羟甲基戊二酰基CoA还原酶类(Hydroxymethylglutaryl CoA Reductases);干扰素γ(Interferon-gamma);动力学(Kinetics);巨噬细胞(Macrophages);小鼠, 近交C57BL(Mice, Inbred C57BL);模型, 生物学(Models, Biological);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);蛋白质组学(Proteomics);RNA(RNA);RNA, 信使(RNA, Messenger);甾类羟化酶类(Steroid Hydroxylases);胆固醇调节元件结合蛋白质1(Sterol Regulatory Element Binding Protein 1);时间因素(Time Factors);转录, 遗传(Transcription, Genetic)
DOI
10.1016/j.steroids.2015.02.022
PMID
25759117
发布时间
2018-11-13
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Steroids
219-29页
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