Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea.

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作者： Changsuk,Moon ^[1] ; Weiqiang,Zhang ^[2] ; Aixia,Ren ^[3] ; Kavisha,Arora ^[1] ; Chandrima,Sinha ^[4] ; Sunitha,Yarlagadda ^[1] ; Koryse,Woodrooffe ^[5] ; John D,Schuetz ^[6] ; Koteswara Rao,Valasani ^[7] ; Hugo R,de Jonge ^[8] ; Shiva Kumar,Shanmukhappa ^[5] ; Mohamed Tarek M,Shata ^[9] ; Randal K,Buddington ^[10] ; Kaushik,Parthasarathi ^[4] ; Anjaparavanda P,Naren ^[11]

作者单位： From the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, the Departments of Physiology and. ^[1] the Departments of Physiology and Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38163. ^[2] the Departments of Physiology and the Departments of Hematology and. ^[3] the Departments of Physiology and. ^[4] From the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229. ^[5] Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105. ^[6] the Department of Pharmacology and Toxicology and Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, Kansas 66047. ^[7] the Department of Gastroenterology and Hepatology, Erasmus University Medical Center, 3000CA Rotterdam, The Netherlands. ^[8] the Division of Digestive Diseases, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, and. ^[9] the Department of Health and Sport Sciences, University of Memphis, Memphis, Tennessee 38152. ^[10] From the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, the Departments of Physiology and anaren@cchmc.org. ^[11]

关键词 ABC Transporter Chloride Channel Chloride Transport Cyclic AMP (cAMP)Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)Drug-induced Secretory Diarrhea Enterosphere MRP4 Multidrug Transporter PDZ Domain