第一作者:
G,Jun
第一单位:
Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
作者:
G,Jun [1]
;
C A,Ibrahim-Verbaas [2]
;
M,Vronskaya [3]
;
J-C,Lambert [4]
;
J,Chung [5]
;
A C,Naj [6]
;
B W,Kunkle [7]
;
L-S,Wang [8]
;
J C,Bis [9]
;
C,Bellenguez [1]
;
D,Harold [10]
;
K L,Lunetta [11]
;
A L,Destefano [10]
;
B,Grenier-Boley [12]
;
R,Sims [7]
;
G W,Beecham [8]
;
A V,Smith [9]
;
V,Chouraki [13]
;
K L,Hamilton-Nelson [3]
;
M A,Ikram [3]
;
N,Fievet [7]
;
N,Denning [8]
;
E R,Martin [9]
;
H,Schmidt [6]
;
Y,Kamatani [11]
;
M L,Dunstan [14]
;
O,Valladares [15]
;
A R,Laza [16]
;
D,Zelenika [17]
;
A,Ramirez [11]
;
T M,Foroud [4]
;
S-H,Choi [18]
;
A,Boland [19]
;
T,Becker [7]
;
W A,Kukull [8]
;
S J,van der Lee [9]
;
F,Pasquier [6]
;
C,Cruchaga [11]
;
D,Beekly [14]
;
A L,Fitzpatrick [20]
;
O,Hanon [21]
;
M,Gill [22]
;
R,Barber [6]
;
V,Gudnason [10]
;
D,Campion [23]
;
S,Love [24]
;
D A,Bennett [25]
;
N,Amin [26]
;
C,Berr [27]
;
Magda,Tsolaki [3]
;
J D,Buxbaum [24]
;
O L,Lopez [28]
;
V,Deramecourt [29]
;
N C,Fox [30]
;
L B,Cantwell [4]
;
L,Tárraga [8]
;
C,Dufouil [31]
;
J,Hardy [32]
;
P K,Crane [33]
;
G,Eiriksdottir [34]
;
D,Hannequin [30]
;
R,Clarke [35]
;
D,Evans [36]
;
T H,Mosley [37]
;
L,Letenneur [38]
;
C,Brayne [39]
;
W,Maier [15]
;
P,De Jager [16]
;
V,Emilsson [40]
;
J-F,Dartigues [41]
;
H,Hampel [41]
;
M I,Kamboh [42]
;
R F A G,de Bruijn [43]
;
C,Tzourio [4]
;
P,Pastor [44]
;
E B,Larson [45]
;
J I,Rotter [46]
;
M C,O'Donovan [47]
;
T J,Montine [48]
;
M A,Nalls [49]
;
S,Mead [50]
;
E M,Reiman [8]
;
P V,Jonsson [31]
;
C,Holmes [51]
;
P H,St George-Hyslop [10]
;
M,Boada [23]
;
P,Passmore [52]
;
J R,Wendland [53]
;
R,Schmidt [54]
;
K,Morgan [55]
;
A R,Winslow [16]
;
J F,Powell [40]
;
M,Carasquillo [52]
;
S G,Younkin [56]
;
J,Jakobsdóttir [57]
;
J S K,Kauwe [58]
;
K C,Wilhelmsen [52]
;
D,Rujescu [59]
;
M M,Nöthen [25]
;
A,Hofman [28]
;
L,Jones [5]
;
IGAP Consortium [60]
;
J L,Haines [61]
;
B M,Psaty [16]
;
C,Van Broeckhoven [62]
;
P,Holmans [52]
;
L J,Launer [63]
;
R,Mayeux [64]
;
M,Lathrop [65]
;
A M,Goate [49]
;
V,Escott-Price [66]
;
S,Seshadri [4]
;
M A,Pericak-Vance [52]
;
P,Amouyel [67]
;
J,Williams [68]
;
C M,van Duijn [55]
;
G D,Schellenberg [69]
;
L A,Farrer [70]
作者单位:
Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
[1]
Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA.
[2]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[3]
Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam,The Netherlands.
[4]
Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam,The Netherlands.
[5]
Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
[6]
Inserm U744, Lille, France.
[7]
Université Lille 2, Lille, France.
[8]
Institut Pasteur de Lille, Lille, France.
[9]
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
[10]
The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
[11]
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
[12]
Trinity College, University of Dublin, Dublin, Ireland.
[13]
Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA.
[14]
University of Iceland, Faculty of Medicine, Reykjavik, Iceland.
[15]
Icelandic Heart Association, Kopavogur, Iceland.
[16]
Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
[17]
Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.
[18]
Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam,The Netherlands.
[19]
Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
[20]
Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, Riken, Kanagawa, Japan.
[21]
Foundation Jean Dausset-CEPH, Paris, France.
[22]
Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain.
[23]
Centre National de Genotypage, Institut Genomique, Commissariat a l'energie Atomique, Evry, France.
[24]
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
[25]
Institute of Human Genetics, University of Bonn, Bonn, Germany.
[26]
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
[27]
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
[28]
Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.
[29]
Department of Epidemiology, University of Washington, Seattle, WA, USA.
[30]
Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France.
[31]
Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St Louis, MO, USA.
[32]
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
[33]
National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA.
[34]
Departments of Health Services, University of Washington, Seattle, WA, USA.
[35]
Department of Geriatrics, University Paris Descartes, Sorbonne Paris V, France.
[36]
Geriatrics Department, Broca Hospital, Paris, France.
[37]
Mercer's Institute for Research on Aging, St James Hospital and Trinity College, Dublin, Ireland.
[38]
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
[39]
CNR-MAJ, Inserm U1079, Rouen, France; University Hospital, 76031 Rouen, France.
[40]
University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK.
[41]
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
[42]
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
[43]
Inserm U888, Hôpital La Colombière, Montpellier, France.
[44]
Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
[45]
Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA.
[46]
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
[47]
Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA.
[48]
University of Pittsburgh Alzheimer's Disease Research Center, Pittsburgh, PA, USA.
[49]
Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
[50]
Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.
[51]
Inserm U897, Victor Segalen University, F-33076, Bordeaux, France.
[52]
Department of Molecular Neuroscience, Institute of Neurology, London, UK.
[53]
Reta Lilla Weston Laboratories, Institute of Neurology, London, UK.
[54]
Department of Medicine, University of Washington, Seattle, WA, USA.
[55]
Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK.
[56]
Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
[57]
Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA.
[58]
Institute of Public Health, University of Cambridge, Cambridge, UK.
[59]
Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology and Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
[60]
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
[61]
Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland.
[62]
Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France.
[63]
Department of Psychiatry, University of Frankfurt, Frankfurt am Main, Germany.
[64]
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany.
[65]
Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
[66]
Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.
[67]
CIBERNED, Instituto de Salud Carlos III, Madrid, Spain.
[68]
Group Health, Group Health Research Institute, Seattle, WA, USA.
[69]
Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
[70]
Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
[71]
Department of Pathology, University of Washington, Seattle, WA, USA.
[72]
Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA.
[73]
Arizona Alzheimer's Consortium, Phoenix, AZ, USA.
[74]
Department of Psychiatry, University of Arizona, Phoenix, AZ, USA.
[75]
Banner Alzheimer's Institute, Phoenix, AZ, USA.
[76]
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona.
[77]
Department of Geriatrics, Landspitali National University Hospital, Reykjavik, Iceland.
[78]
Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
[79]
Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON, Canada.
[80]
Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
[81]
Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.
[82]
PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
[83]
Department of Neurology, Medical University of Graz, Graz, Austria.
[84]
Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
[85]
King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, UK.
[86]
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
[87]
Department of Biology, Brigham Young University, Provo, Utah, USA.
[88]
Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.
[89]
Department of Psychiatry, Psychotherapy and Psychosomatics Martin-Luther-University Halle-Wittenberg, Halle, Germany.
[90]
Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
[91]
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
[92]
Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.
[93]
Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
[94]
Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USA.
[95]
Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
[96]
Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.
[97]
Department of Neurology, Columbia University, New York, NY, USA.
[98]
McGill University and Génome Québec Innovation Centre, Montreal, QC, Canada.
[99]
University Hospital, CHRU Lille, Lille, France.
[100]
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
[101]
主题词
阿尔茨海默病(Alzheimer Disease);载脂蛋白E4(Apolipoprotein E4);染色体, 人, 17对(Chromosomes, Human, Pair 17);全基因组关联研究(Genome-Wide Association Study);人类(Humans);多态性, 单核苷酸(Polymorphism, Single Nucleotide);tau蛋白质类(tau Proteins)
DOI
10.1038/mp.2015.23
PMID
25778476
发布时间
2023-07-14
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Molecular psychiatry
Molecular psychiatry
108-17页
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