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A novel Alzheimer disease locus located near the gene encoding tau protein.

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第一作者: G,Jun
第一单位: Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
作者: G,Jun [1] ; C A,Ibrahim-Verbaas [2] ; M,Vronskaya [3] ; J-C,Lambert [4] ; J,Chung [5] ; A C,Naj [6] ; B W,Kunkle [7] ; L-S,Wang [8] ; J C,Bis [9] ; C,Bellenguez [1] ; D,Harold [10] ; K L,Lunetta [11] ; A L,Destefano [10] ; B,Grenier-Boley [12] ; R,Sims [7] ; G W,Beecham [8] ; A V,Smith [9] ; V,Chouraki [13] ; K L,Hamilton-Nelson [3] ; M A,Ikram [3] ; N,Fievet [7] ; N,Denning [8] ; E R,Martin [9] ; H,Schmidt [6] ; Y,Kamatani [11] ; M L,Dunstan [14] ; O,Valladares [15] ; A R,Laza [16] ; D,Zelenika [17] ; A,Ramirez [11] ; T M,Foroud [4] ; S-H,Choi [18] ; A,Boland [19] ; T,Becker [7] ; W A,Kukull [8] ; S J,van der Lee [9] ; F,Pasquier [6] ; C,Cruchaga [11] ; D,Beekly [14] ; A L,Fitzpatrick [20] ; O,Hanon [21] ; M,Gill [22] ; R,Barber [6] ; V,Gudnason [10] ; D,Campion [23] ; S,Love [24] ; D A,Bennett [25] ; N,Amin [26] ; C,Berr [27] ; Magda,Tsolaki [3] ; J D,Buxbaum [24] ; O L,Lopez [28] ; V,Deramecourt [29] ; N C,Fox [30] ; L B,Cantwell [4] ; L,Tárraga [8] ; C,Dufouil [31] ; J,Hardy [32] ; P K,Crane [33] ; G,Eiriksdottir [34] ; D,Hannequin [30] ; R,Clarke [35] ; D,Evans [36] ; T H,Mosley [37] ; L,Letenneur [38] ; C,Brayne [39] ; W,Maier [15] ; P,De Jager [16] ; V,Emilsson [40] ; J-F,Dartigues [41] ; H,Hampel [41] ; M I,Kamboh [42] ; R F A G,de Bruijn [43] ; C,Tzourio [4] ; P,Pastor [44] ; E B,Larson [45] ; J I,Rotter [46] ; M C,O'Donovan [47] ; T J,Montine [48] ; M A,Nalls [49] ; S,Mead [50] ; E M,Reiman [8] ; P V,Jonsson [31] ; C,Holmes [51] ; P H,St George-Hyslop [10] ; M,Boada [23] ; P,Passmore [52] ; J R,Wendland [53] ; R,Schmidt [54] ; K,Morgan [55] ; A R,Winslow [16] ; J F,Powell [40] ; M,Carasquillo [52] ; S G,Younkin [56] ; J,Jakobsdóttir [57] ; J S K,Kauwe [58] ; K C,Wilhelmsen [52] ; D,Rujescu [59] ; M M,Nöthen [25] ; A,Hofman [28] ; L,Jones [5] ; IGAP Consortium [60] ; J L,Haines [61] ; B M,Psaty [16] ; C,Van Broeckhoven [62] ; P,Holmans [52] ; L J,Launer [63] ; R,Mayeux [64] ; M,Lathrop [65] ; A M,Goate [49] ; V,Escott-Price [66] ; S,Seshadri [4] ; M A,Pericak-Vance [52] ; P,Amouyel [67] ; J,Williams [68] ; C M,van Duijn [55] ; G D,Schellenberg [69] ; L A,Farrer [70]
作者单位: Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA. [1] Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA. [2] Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. [3] Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam,The Netherlands. [4] Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam,The Netherlands. [5] Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. [6] Inserm U744, Lille, France. [7] Université Lille 2, Lille, France. [8] Institut Pasteur de Lille, Lille, France. [9] Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. [10] The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA. [11] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. [12] Trinity College, University of Dublin, Dublin, Ireland. [13] Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA. [14] University of Iceland, Faculty of Medicine, Reykjavik, Iceland. [15] Icelandic Heart Association, Kopavogur, Iceland. [16] Department of Neurology, Boston University School of Medicine, Boston, MA, USA. [17] Netherlands Consortium for Healthy Aging, Leiden, The Netherlands. [18] Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam,The Netherlands. [19] Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria. [20] Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, Riken, Kanagawa, Japan. [21] Foundation Jean Dausset-CEPH, Paris, France. [22] Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain. [23] Centre National de Genotypage, Institut Genomique, Commissariat a l'energie Atomique, Evry, France. [24] Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. [25] Institute of Human Genetics, University of Bonn, Bonn, Germany. [26] Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA. [27] German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. [28] Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany. [29] Department of Epidemiology, University of Washington, Seattle, WA, USA. [30] Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France. [31] Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St Louis, MO, USA. [32] Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. [33] National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA. [34] Departments of Health Services, University of Washington, Seattle, WA, USA. [35] Department of Geriatrics, University Paris Descartes, Sorbonne Paris V, France. [36] Geriatrics Department, Broca Hospital, Paris, France. [37] Mercer's Institute for Research on Aging, St James Hospital and Trinity College, Dublin, Ireland. [38] Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA. [39] CNR-MAJ, Inserm U1079, Rouen, France; University Hospital, 76031 Rouen, France. [40] University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK. [41] Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. [42] Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. [43] Inserm U888, Hôpital La Colombière, Montpellier, France. [44] Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece. [45] Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA. [46] Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA. [47] Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA. [48] University of Pittsburgh Alzheimer's Disease Research Center, Pittsburgh, PA, USA. [49] Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. [50] Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK. [51] Inserm U897, Victor Segalen University, F-33076, Bordeaux, France. [52] Department of Molecular Neuroscience, Institute of Neurology, London, UK. [53] Reta Lilla Weston Laboratories, Institute of Neurology, London, UK. [54] Department of Medicine, University of Washington, Seattle, WA, USA. [55] Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK. [56] Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA. [57] Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA. [58] Institute of Public Health, University of Cambridge, Cambridge, UK. [59] Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology and Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. [60] Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. [61] Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland. [62] Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France. [63] Department of Psychiatry, University of Frankfurt, Frankfurt am Main, Germany. [64] Department of Psychiatry, Ludwig Maximilians University, Munich, Germany. [65] Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA. [66] Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain. [67] CIBERNED, Instituto de Salud Carlos III, Madrid, Spain. [68] Group Health, Group Health Research Institute, Seattle, WA, USA. [69] Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. [70] Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA. [71] Department of Pathology, University of Washington, Seattle, WA, USA. [72] Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA. [73] Arizona Alzheimer's Consortium, Phoenix, AZ, USA. [74] Department of Psychiatry, University of Arizona, Phoenix, AZ, USA. [75] Banner Alzheimer's Institute, Phoenix, AZ, USA. [76] Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona. [77] Department of Geriatrics, Landspitali National University Hospital, Reykjavik, Iceland. [78] Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK. [79] Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON, Canada. [80] Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. [81] Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK. [82] PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA. [83] Department of Neurology, Medical University of Graz, Graz, Austria. [84] Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK. [85] King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, UK. [86] Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. [87] Department of Biology, Brigham Young University, Provo, Utah, USA. [88] Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA. [89] Department of Psychiatry, Psychotherapy and Psychosomatics Martin-Luther-University Halle-Wittenberg, Halle, Germany. [90] Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. [91] Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA. [92] Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium. [93] Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. [94] Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USA. [95] Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. [96] Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA. [97] Department of Neurology, Columbia University, New York, NY, USA. [98] McGill University and Génome Québec Innovation Centre, Montreal, QC, Canada. [99] University Hospital, CHRU Lille, Lille, France. [100] Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA. [101]
DOI 10.1038/mp.2015.23
PMID 25778476
发布时间 2023-07-14
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