Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.-论文-万方医学网

作者： Joel D,Leverson ^[1] ; Darren C,Phillips ^[2] ; Michael J,Mitten ^[2] ; Erwin R,Boghaert ^[2] ; Dolores,Diaz ^[3] ; Stephen K,Tahir ^[2] ; Lisa D,Belmont ^[3] ; Paul,Nimmer ^[2] ; Yu,Xiao ^[2] ; Xiaoju Max,Ma ^[3] ; Kym N,Lowes ^[4] ; Peter,Kovar ^[2] ; Jun,Chen ^[2] ; Sha,Jin ^[2] ; Morey,Smith ^[2] ; John,Xue ^[2] ; Haichao,Zhang ^[2] ; Anatol,Oleksijew ^[2] ; Terrance J,Magoc ^[2] ; Kedar S,Vaidya ^[2] ; Daniel H,Albert ^[2] ; Jacqueline M,Tarrant ^[3] ; Nghi,La ^[3] ; Le,Wang ^[2] ; Zhi-Fu,Tao ^[2] ; Michael D,Wendt ^[2] ; Deepak,Sampath ^[3] ; Saul H,Rosenberg ^[2] ; Chris,Tse ^[2] ; David C S,Huang ^[4] ; Wayne J,Fairbrother ^[3] ; Steven W,Elmore ^[2] ; Andrew J,Souers ^[2]

作者单位： AbbVie Inc., North Chicago, IL 60064, USA. joel.leverson@abbvie.com. ^[1] AbbVie Inc., North Chicago, IL 60064, USA. ^[2] Genentech Inc., South San Francisco, CA 94080, USA. ^[3] Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia. Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia. ^[4]

主题词投药, 口服(Administration, Oral);苯胺化合物(Aniline Compounds);动物(Animals);抗肿瘤药(Antineoplastic Agents);苯并噻唑类(Benzothiazoles);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);基因表达谱(Gene Expression Profiling);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);粒细胞(Granulocytes);人类(Humans);异喹啉类(Isoquinolines);动力学(Kinetics);小鼠(Mice);肿瘤移植(Neoplasm Transplantation);肿瘤(Neoplasms);中性粒细胞减少(Neutropenia);中性白细胞(Neutrophils);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);磺胺类(Sulfonamides);紫杉烷类(Taxoids);血小板减少(Thrombocytopenia);bcl-X蛋白质(bcl-X Protein)

DOI 10.1126/scitranslmed.aaa4642

PMID 25787766

发布时间 2022-07-08

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Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.

Science translational medicine

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Science translational medicine

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Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.

Science translational medicine

相似文献

Science translational medicine

相关期刊

检索历史清除