第一单位：
1] Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK [2] Department of Biomedicine, Research Group Human Genomics, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
作者：
Michal,Kovac [1]
;
Carolina,Navas [2]
;
Stuart,Horswell [3]
;
Max,Salm [3]
;
Chiara,Bardella [4]
;
Andrew,Rowan [2]
;
Mark,Stares [2]
;
Francesc,Castro-Giner [4]
;
Rosalie,Fisher [2]
;
Elza C,de Bruin [5]
;
Monika,Kovacova [6]
;
Maggie,Gorman [4]
;
Seiko,Makino [4]
;
Jennet,Williams [4]
;
Emma,Jaeger [4]
;
Angela,Jones [4]
;
Kimberley,Howarth [4]
;
James,Larkin [7]
;
Lisa,Pickering [7]
;
Martin,Gore [7]
;
David L,Nicol [8]
;
Steven,Hazell [9]
;
Gordon,Stamp [10]
;
Tim,O'Brien [11]
;
Ben,Challacombe [11]
;
Nik,Matthews [12]
;
Benjamin,Phillimore [12]
;
Sharmin,Begum [12]
;
Adam,Rabinowitz [12]
;
Ignacio,Varela [13]
;
Ashish,Chandra [14]
;
Catherine,Horsfield [14]
;
Alexander,Polson [14]
;
Maxine,Tran [15]
;
Rupesh,Bhatt [16]
;
Luigi,Terracciano [17]
;
Serenella,Eppenberger-Castori [17]
;
Andrew,Protheroe [18]
;
Eamonn,Maher [19]
;
Mona,El Bahrawy [20]
;
Stewart,Fleming [21]
;
Peter,Ratcliffe [22]
;
Karl,Heinimann [23]
;
Charles,Swanton [24]
;
Ian,Tomlinson [25]
作者单位：
1] Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK [2] Department of Biomedicine, Research Group Human Genomics, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
[1]
Translational Cancer Therapeutics Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
[2]
Bioinformatics and Biostatistics, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
[3]
Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
[4]
University College London Cancer Institute and Hospitals, Huntley Street, London WC1E 6DD, UK.
[5]
Faculty of Mechanical Engineering, Institute of Mathematics and Physics, Slovak University of Technology, Namestie slobody 17, 812 31 Bratislava, Slovakia.
[6]
Department of Medicine, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK.
[7]
1] Department of Urology, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK [2] School of Medicine, University of Queensland, Brisbane, Australia.
[8]
Department of Histopathology, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK.
[9]
Experimental Histopathology, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
[10]
Urology Centre, Guy's and St Thomas's Hospital NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.
[11]
Advanced Sequencing Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK.
[12]
Genomic analysis of tumour development, Instituto de Biomedicina y Biotecnología de Cantabria (CSIC-UC-Sodercan), Departamento de Biología Molecular, Universidad de Cantabria, 39011 Santander, Spain.
[13]
Department of Histopathology, Guy's and St Thomas's Hospital NHS Foundation Trust, Great Maze Pond, London SE1 9RT, UK.
[14]
Department of Oncology, Uro-Oncology Research Group, University of Cambridge, Cambridge CB2 0RE, UK.
[15]
Department of Urology, University Hospitals, Birmingham B15 2TH, UK.
[16]
Institute for Pathology, University Hospital Basel, Schönbeinstrasse 40, 4003 Basel, Switzerland.
[17]
Department of Oncology, Cancer and Haematology Centre, Churchill Hospital, Oxford University Hospitals, Oxford OX3 7LJ, UK.
[18]
Department of Medical Genetics, University of Cambridge, Cambridge CB2 0QQ, UK.
[19]
Department of Histopathology, Imperial College London, Hammersmith Hospital, London W12 0HS, UK.
[20]
Department of Histopathology, Medical Research Institute, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK.
[21]
Hypoxia Biology Laboratory, Henry Wellcome Building for Molecular Physiology, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
[22]
Department of Biomedicine, Research Group Human Genomics, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.
[23]
1] Translational Cancer Therapeutics Laboratory, London Research Institute, Cancer Research UK, 44, Lincoln's Inn Fields, London WC2A 3LY, UK [2] University College London Cancer Institute and Hospitals, Huntley Street, London WC1E 6DD, UK.
[24]
1] Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK [2] NIHR Comprehensive Biomedical Research Centre, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
[25]
医学主题词
成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);抗体, 单克隆(Antibodies, Monoclonal);癌, 肾细胞(Carcinoma, Renal Cell);染色体图(Chromosome Mapping);染色体(Chromosomes);DNA拷贝数变异(DNA Copy Number Variations);外显子(Exons);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);组蛋白赖氨酸N-甲基转移酶(Histone-Lysine N-Methyltransferase);人类(Humans);肾肿瘤(Kidney Neoplasms);杂合子丢失(Loss of Heterozygosity);男(雄)性(Male);中年人(Middle Aged);突变(Mutation);种系发生(Phylogeny);多态性, 单核苷酸(Polymorphism, Single Nucleotide);序列分析, DNA(Sequence Analysis, DNA)
DOI
10.1038/ncomms7336
PMID
25790038
发布时间
2025-05-29
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