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Quantification and simulation of layer-specific mitral valve interstitial cells deformation under physiological loading.

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第一作者： Chung-Hao,Lee

第一单位： Center for Cardiovascular Simulation, Institute for Computational Engineering and Sciences (ICES), Department of Biomedical Engineering, The University of Texas at Austin, 201 East 24th Street, POB 5.236, 1 University Station C0200, Austin, TX 78712, USA.

作者： Chung-Hao,Lee ^[1] ; Christopher A,Carruthers ^[2] ; Salma,Ayoub ^[1] ; Robert C,Gorman ^[3] ; Joseph H,Gorman ^[3] ; Michael S,Sacks ^[4]

作者单位： Center for Cardiovascular Simulation, Institute for Computational Engineering and Sciences (ICES), Department of Biomedical Engineering, The University of Texas at Austin, 201 East 24th Street, POB 5.236, 1 University Station C0200, Austin, TX 78712, USA. ^[1] Cardiac Rhythm Disease Management (CRDM) Clinical Specialist, Medtronic, Minneapolis, MN 55432, USA. ^[2] Gorman Cardiovascular Research Group, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA. ^[3] Center for Cardiovascular Simulation, Institute for Computational Engineering and Sciences (ICES), Department of Biomedical Engineering, The University of Texas at Austin, 201 East 24th Street, POB 5.236, 1 University Station C0200, Austin, TX 78712, USA. Electronic address: msacks@ices.utexas.edu. ^[4]

关键词 Finite element simulations MPM imaging analysis MVIC microenvironment Multi-level macro–micro modeling Simplified structural constitutive model