Azide-alkyne cycloaddition-mediated cyclization of phosphonopeptides and their evaluation as PTP1B binders and enrichment tools.

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作者： Christoph,Meyer ^[1] ; Birgit,Hoeger ^[1] ; Jayanta,Chatterjee ^[1] ; Maja,Köhn ^[2]

作者单位： European Molecular Biology Laboratory, Genome Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany. ^[1] European Molecular Biology Laboratory, Genome Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Electronic address: koehn@embl.de. ^[2]

关键词 Azide–alkyne click chemistry Cyclic peptides PTP1B and TCPTP Protein tyrosine phosphatases Pull-down baits

主题词炔类(Alkynes);叠氮化合物(Azides);人类(Humans);肽类, 环(Peptides, Cyclic);蛋白质酪氨酸磷酸酶, 非受体1型(Protein Tyrosine Phosphatase, Non-Receptor Type 1);蛋白质酪氨酸磷酸酶, 非受体2型(Protein Tyrosine Phosphatase, Non-Receptor Type 2)

DOI 10.1016/j.bmc.2015.03.015

PMID 25805211

发布时间 2015-06-01

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