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A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility.

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作者: F David,Carmona [1] ; Sarah L,Mackie [2] ; Jose-Ezequiel,Martín [3] ; John C,Taylor [4] ; Augusto,Vaglio [5] ; Stephen,Eyre [6] ; Lara,Bossini-Castillo [3] ; Santos,Castañeda [7] ; Maria C,Cid [8] ; José,Hernández-Rodríguez [8] ; Sergio,Prieto-González [8] ; Roser,Solans [9] ; Marc,Ramentol-Sintas [9] ; M Francisca,González-Escribano [10] ; Lourdes,Ortiz-Fernández [10] ; Inmaculada C,Morado [11] ; Javier,Narváez [12] ; José A,Miranda-Filloy [13] ; Spanish GCA Group [14] ; Lorenzo,Beretta [15] ; Claudio,Lunardi [16] ; Marco A,Cimmino [17] ; Davide,Gianfreda [18] ; Daniele,Santilli [19] ; Giuseppe A,Ramirez [20] ; Alessandra,Soriano [21] ; Francesco,Muratore [21] ; Giulia,Pazzola [21] ; Olga,Addimanda [22] ; Cisca,Wijmenga [23] ; Torsten,Witte [24] ; Jan H,Schirmer [24] ; Frank,Moosig [25] ; Verena,Schönau [26] ; Andre,Franke [27] ; Øyvind,Palm [27] ; Øyvind,Molberg [28] ; Andreas P,Diamantopoulos [29] ; Simon,Carette [30] ; David,Cuthbertson [31] ; Lindsy J,Forbess [32] ; Gary S,Hoffman [33] ; Nader A,Khalidi [34] ; Curry L,Koening [32] ; Carol A,Langford [35] ; Carol A,McAlear [36] ; Larry,Moreland [37] ; Paul A,Monach [29] ; Christian,Pagnoux [38] ; Philip,Seo [39] ; Robert,Spiera [35] ; Antoine G,Sreih [40] ; Kenneth J,Warrington [40] ; Steven R,Ytterberg [41] ; Peter K,Gregersen [42] ; Colin T,Pease [43] ; Andrew,Gough [44] ; Michael,Green [45] ; Lesley,Hordon [46] ; Stephen,Jarrett [47] ; Richard,Watts [48] ; Sarah,Levy [49] ; Yusuf,Patel [50] ; Sanjeet,Kamath [51] ; Bhaskar,Dasgupta [6] ; Jane,Worthington [52] ; Bobby P C,Koeleman [53] ; Paul I W,de Bakker [4] ; Jennifer H,Barrett [21] ; Carlo,Salvarani [35] ; Peter A,Merkel [54] ; Miguel A,González-Gay [4] ; Ann W,Morgan [3] ; Javier,Martín
作者单位: Instituto de Parasitología y Biomedicina "López-Neyra," CSIC, PTS Granada, Granada 18016, Spain. Electronic address: dcarmona@ipb.csic.es. [1] Leeds Institute of Rheumatic and Musculoskeletal Medicine and NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds LS7 4SA, UK. [2] Instituto de Parasitología y Biomedicina "López-Neyra," CSIC, PTS Granada, Granada 18016, Spain. [3] School of Medicine and NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds LS9 7TF, UK. [4] Unit of Nephrology, University Hospital of Parma, Parma 43126, Italy. [5] NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, UK; Arthritis Research UK Epidemiology Unit, University Of Manchester, Manchester M13 9NT, UK. [6] Department of Rheumatology, Hospital de la Princesa, IIS-Princesa, Madrid 28006, Spain. [7] Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain. [8] Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona 08035, Spain. [9] Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), Sevilla 41013, Spain. [10] Department of Rheumatology, Hospital Clínico San Carlos, Madrid 28040, Spain. [11] Department of Rheumatology, Hospital Universitario de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08907, Spain. [12] Department of Rheumatology, Hospital Xeral-Calde, Lugo 27004, Spain. [13] Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan 20122, Italy. [14] Department of Medicine, Universita degli Studi di Verona, Verona 37134, Italy. [15] Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova 16132, Italy. [16] Department of Clinical and Experimental Medicine, University of Parma, School of Medicine, Parma 43126, Italy. [17] Unit of Internal Medicine and Rheumatology, University Hospital of Parma, Parma 43126, Italy. [18] Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milan 20132, Italy. [19] Department of Clinical Medicine and Rheumatology, Campus Bio-Medico University, Rome 00128, Italy. [20] Rheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia 42123, Italy. [21] Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9700, the Netherlands. [22] Hannover Medical School, Hannover 30625, Germany. [23] Vasculitis Clinic, Klinikum Bad Bramstedt & University Hospital of Schleswig Holstein, Bad Bramstedt 24576, Germany. [24] Department of Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen 91054, Germany. [25] Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel 24105, Germany. [26] Department of Rheumatology, Oslo University Hospital, Oslo 0424, Norway. [27] Department of Rheumatology, Hospital of Southern Norway Trust, Kristiansand 4604, Norway. [28] Division of Rheumatology, Mount Sinai Hospital, Toronto, ON M5T 3L9, Canada. [29] Department of Biostatistics, University of South Florida, Tampa, FL 33612, USA. [30] Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. [31] Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. [32] Division of Rheumatology, St. Joseph's Healthcare, McMaster University, Hamilton, ON L8N 1Y2, Canada. [33] Division of Rheumatology, University of Utah, Salt Lake City, UT 84132, USA. [34] Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104, USA. [35] Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA. [36] Section of Rheumatology, Boston University School of Medicine, Boston, MA 02118, USA. [37] Division of Rheumatology, Johns Hopkins University, Baltimore, MD 21224, USA. [38] Department of Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA. [39] Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. [40] The Feinstein Institute for Medical Research, North Shore - Long Island Jewish Health System, Manhasset, NY 11030, USA. [41] Department of Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds LS7 4SA, UK. [42] Department of Rheumatology, Harrogate and District NHS Foundation Trust, Harrogate HG2 7SX, UK. [43] Department of Rheumatology, York Teaching Hospital NHS Foundation Trust, York YO31 8HE, UK. [44] Department of Rheumatology, Mid Yorkshire Hospitals NHS Trust, Dewsbury and District Hospital, Dewsbury WF13 4HS, UK. [45] Department of Rheumatology, Mid Yorkshire Hospitals NHS Trust, Pinderfields Hospital, Wakefield WF1 4DG, UK. [46] Department of Rheumatology, Ipswich Hospital NHS Trust, Ipswich IP4 5PD, UK. [47] Department of Rheumatology, Croydon Health Service NHS Trust, Croydon CR7 7YE, UK. [48] Department of Rheumatology, Hull and East Yorkshire NHS Trust, Hull HU3 2JZ, UK. [49] Department of Rheumatology, Staffordshire and Stoke-on-Trent Partnership NHS Trust, Staffordshire ST6 7AG, UK. [50] Department of Rheumatology, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea SS0 0RY, UK. [51] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands. [52] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands. [53] Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander 39008, Spain. [54]
DOI 10.1016/j.ajhg.2015.02.009
PMID 25817017
发布时间 2022-12-07
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