A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility.
作者:
F David,Carmona [1]
;
Sarah L,Mackie [2]
;
Jose-Ezequiel,Martín [3]
;
John C,Taylor [4]
;
Augusto,Vaglio [5]
;
Stephen,Eyre [6]
;
Lara,Bossini-Castillo [3]
;
Santos,Castañeda [7]
;
Maria C,Cid [8]
;
José,Hernández-Rodríguez [8]
;
Sergio,Prieto-González [8]
;
Roser,Solans [9]
;
Marc,Ramentol-Sintas [9]
;
M Francisca,González-Escribano [10]
;
Lourdes,Ortiz-Fernández [10]
;
Inmaculada C,Morado [11]
;
Javier,Narváez [12]
;
José A,Miranda-Filloy [13]
;
Spanish GCA Group [14]
;
Lorenzo,Beretta [15]
;
Claudio,Lunardi [16]
;
Marco A,Cimmino [17]
;
Davide,Gianfreda [18]
;
Daniele,Santilli [19]
;
Giuseppe A,Ramirez [20]
;
Alessandra,Soriano [21]
;
Francesco,Muratore [21]
;
Giulia,Pazzola [21]
;
Olga,Addimanda [22]
;
Cisca,Wijmenga [23]
;
Torsten,Witte [24]
;
Jan H,Schirmer [24]
;
Frank,Moosig [25]
;
Verena,Schönau [26]
;
Andre,Franke [27]
;
Øyvind,Palm [27]
;
Øyvind,Molberg [28]
;
Andreas P,Diamantopoulos [29]
;
Simon,Carette [30]
;
David,Cuthbertson [31]
;
Lindsy J,Forbess [32]
;
Gary S,Hoffman [33]
;
Nader A,Khalidi [34]
;
Curry L,Koening [32]
;
Carol A,Langford [35]
;
Carol A,McAlear [36]
;
Larry,Moreland [37]
;
Paul A,Monach [29]
;
Christian,Pagnoux [38]
;
Philip,Seo [39]
;
Robert,Spiera [35]
;
Antoine G,Sreih [40]
;
Kenneth J,Warrington [40]
;
Steven R,Ytterberg [41]
;
Peter K,Gregersen [42]
;
Colin T,Pease [43]
;
Andrew,Gough [44]
;
Michael,Green [45]
;
Lesley,Hordon [46]
;
Stephen,Jarrett [47]
;
Richard,Watts [48]
;
Sarah,Levy [49]
;
Yusuf,Patel [50]
;
Sanjeet,Kamath [51]
;
Bhaskar,Dasgupta [6]
;
Jane,Worthington [52]
;
Bobby P C,Koeleman [53]
;
Paul I W,de Bakker [4]
;
Jennifer H,Barrett [21]
;
Carlo,Salvarani [35]
;
Peter A,Merkel [54]
;
Miguel A,González-Gay [4]
;
Ann W,Morgan [3]
;
Javier,Martín
作者单位:
Instituto de Parasitología y Biomedicina "López-Neyra," CSIC, PTS Granada, Granada 18016, Spain. Electronic address: dcarmona@ipb.csic.es.
[1]
Leeds Institute of Rheumatic and Musculoskeletal Medicine and NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds LS7 4SA, UK.
[2]
Instituto de Parasitología y Biomedicina "López-Neyra," CSIC, PTS Granada, Granada 18016, Spain.
[3]
School of Medicine and NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds LS9 7TF, UK.
[4]
Unit of Nephrology, University Hospital of Parma, Parma 43126, Italy.
[5]
NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, UK; Arthritis Research UK Epidemiology Unit, University Of Manchester, Manchester M13 9NT, UK.
[6]
Department of Rheumatology, Hospital de la Princesa, IIS-Princesa, Madrid 28006, Spain.
[7]
Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain.
[8]
Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona 08035, Spain.
[9]
Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), Sevilla 41013, Spain.
[10]
Department of Rheumatology, Hospital Clínico San Carlos, Madrid 28040, Spain.
[11]
Department of Rheumatology, Hospital Universitario de Bellvitge-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08907, Spain.
[12]
Department of Rheumatology, Hospital Xeral-Calde, Lugo 27004, Spain.
[13]
Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan 20122, Italy.
[14]
Department of Medicine, Universita degli Studi di Verona, Verona 37134, Italy.
[15]
Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova 16132, Italy.
[16]
Department of Clinical and Experimental Medicine, University of Parma, School of Medicine, Parma 43126, Italy.
[17]
Unit of Internal Medicine and Rheumatology, University Hospital of Parma, Parma 43126, Italy.
[18]
Unit of Internal Medicine and Immunology, IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milan 20132, Italy.
[19]
Department of Clinical Medicine and Rheumatology, Campus Bio-Medico University, Rome 00128, Italy.
[20]
Rheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera Arcispedale Santa Maria Nuova, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia 42123, Italy.
[21]
Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9700, the Netherlands.
[22]
Hannover Medical School, Hannover 30625, Germany.
[23]
Vasculitis Clinic, Klinikum Bad Bramstedt & University Hospital of Schleswig Holstein, Bad Bramstedt 24576, Germany.
[24]
Department of Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen 91054, Germany.
[25]
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel 24105, Germany.
[26]
Department of Rheumatology, Oslo University Hospital, Oslo 0424, Norway.
[27]
Department of Rheumatology, Hospital of Southern Norway Trust, Kristiansand 4604, Norway.
[28]
Division of Rheumatology, Mount Sinai Hospital, Toronto, ON M5T 3L9, Canada.
[29]
Department of Biostatistics, University of South Florida, Tampa, FL 33612, USA.
[30]
Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
[31]
Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
[32]
Division of Rheumatology, St. Joseph's Healthcare, McMaster University, Hamilton, ON L8N 1Y2, Canada.
[33]
Division of Rheumatology, University of Utah, Salt Lake City, UT 84132, USA.
[34]
Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104, USA.
[35]
Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
[36]
Section of Rheumatology, Boston University School of Medicine, Boston, MA 02118, USA.
[37]
Division of Rheumatology, Johns Hopkins University, Baltimore, MD 21224, USA.
[38]
Department of Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA.
[39]
Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
[40]
The Feinstein Institute for Medical Research, North Shore - Long Island Jewish Health System, Manhasset, NY 11030, USA.
[41]
Department of Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds LS7 4SA, UK.
[42]
Department of Rheumatology, Harrogate and District NHS Foundation Trust, Harrogate HG2 7SX, UK.
[43]
Department of Rheumatology, York Teaching Hospital NHS Foundation Trust, York YO31 8HE, UK.
[44]
Department of Rheumatology, Mid Yorkshire Hospitals NHS Trust, Dewsbury and District Hospital, Dewsbury WF13 4HS, UK.
[45]
Department of Rheumatology, Mid Yorkshire Hospitals NHS Trust, Pinderfields Hospital, Wakefield WF1 4DG, UK.
[46]
Department of Rheumatology, Ipswich Hospital NHS Trust, Ipswich IP4 5PD, UK.
[47]
Department of Rheumatology, Croydon Health Service NHS Trust, Croydon CR7 7YE, UK.
[48]
Department of Rheumatology, Hull and East Yorkshire NHS Trust, Hull HU3 2JZ, UK.
[49]
Department of Rheumatology, Staffordshire and Stoke-on-Trent Partnership NHS Trust, Staffordshire ST6 7AG, UK.
[50]
Department of Rheumatology, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea SS0 0RY, UK.
[51]
Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands.
[52]
Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, the Netherlands.
[53]
Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander 39008, Spain.
[54]
主题词
队列研究(Cohort Studies);基因, MHCⅡ类(Genes, MHC Class II);遗传关联研究(Genetic Association Studies);基因型(Genotype);巨细胞动脉炎(Giant Cell Arteritis);人类(Humans);多因子遗传(Multifactorial Inheritance);多元分析(Multivariate Analysis);比值比(Odds Ratio)
DOI
10.1016/j.ajhg.2015.02.009
PMID
25817017
发布时间
2022-12-07
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American journal of human genetics
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