Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing.-论文-万方医学网

作者： Rozanne,Arulanandam ^[1] ; Cory,Batenchuk ^[1] ; Oliver,Varette ^[1] ; Chadi,Zakaria ^[2] ; Vanessa,Garcia ^[1] ; Nicole E,Forbes ^[1] ; Colin,Davis ^[1] ; Ramya,Krishnan ^[1] ; Raunak,Karmacharya ^[1] ; Julie,Cox ^[1] ; Anisha,Sinha ^[1] ; Andrew,Babawy ^[1] ; Katherine,Waite ^[1] ; Erica,Weinstein ^[1] ; Theresa,Falls ^[1] ; Andrew,Chen ^[1] ; Jeff,Hamill ^[1] ; Naomi,De Silva ^[1] ; David P,Conrad ^[1] ; Harold,Atkins ^[1] ; Kenneth,Garson ^[1] ; Carolina,Ilkow ^[1] ; Mads,Kærn ^[3] ; Barbara,Vanderhyden ^[1] ; Nahum,Sonenberg ^[2] ; Tommy,Alain ^[4] ; Fabrice,Le Boeuf ^[1] ; John C,Bell ^[1] ; Jean-Simon,Diallo ^[1]

作者单位： Center for Innovative Cancer Research, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6. ^[1] Department of Biochemistry, Goodman Cancer Center, McGill University, 1160 Pine Avenue West, Montréal, Quebec, Canada H3A 1A3. ^[2] Ottawa Institute of Systems Biology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5. ^[3] Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario, Canada K1H 8L1. ^[4]

主题词阿苯达唑(Albendazole);动物(Animals);苯咪唑类(Benzimidazoles);旁观者效应(Bystander Effect);细胞系(Cell Line);细胞系, 肿瘤(Cell Line, Tumor);秋水仙碱(Colchicine);细胞因子类(Cytokines);HT29细胞(HT29 Cells);人类(Humans);干扰素Ⅰ型(Interferon Type I);小鼠(Mice);微管(Microtubules);诺考达唑(Nocodazole);溶瘤病毒疗法(Oncolytic Virotherapy);溶瘤病毒(Oncolytic Viruses);蛋白质生物合成(Protein Biosynthesis);RNA, 信使(RNA, Messenger);弹状病毒科(Rhabdoviridae);弹状病毒科感染(Rhabdoviridae Infections);微管蛋白调节因子(Tubulin Modulators);Vero细胞(Vero Cells);长春碱(Vinblastine)

DOI 10.1038/ncomms7410

PMID 25817275

发布时间 2020-12-22

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Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing.

Nature communications

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Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing.

Nature communications

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Nature communications

相关期刊

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