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Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs.

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第一作者： Corinne,Beinat

第一单位： School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia; Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

作者： Corinne,Beinat ^[1] ; Tristan,Reekie ^[2] ; Samuel D,Banister ^[3] ; James,O'Brien-Brown ^[2] ; Teresa,Xie ^[4] ; Thao T,Olson ^[4] ; Yingxian,Xiao ^[4] ; Andrew,Harvey ^[5] ; Susan,O'Connor ^[5] ; Carolyn,Coles ^[5] ; Anton,Grishin ^[5] ; Peter,Kolesik ^[5] ; John,Tsanaktsidis ^[6] ; Michael,Kassiou ^[7]

作者单位： School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia; Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA. ^[1] School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. ^[2] Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA. ^[3] Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20057, USA. ^[4] Bionomics Limited, Thebarton, SA 5031, Australia. ^[5] CSIRO Materials Science & Engineering, Ian Wark Laboratory, Bayview Avenue, Clayton, Victoria 3168, Australia. ^[6] School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia; Faculty of Health Sciences, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address: michael.kassiou@sydney.edu.au. ^[7]

关键词 Acetylcholine receptor CNS Structure–activity relationships α7 nicotinic receptors