Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1.-论文-万方医学网

第一作者： Adeline,Gasser

第一单位： Biotechnology and Cell Signaling Laboratory (UMR 7242), CNRS-University of Strasbourg, Illkirch, France.

作者： Adeline,Gasser ^[1] ; Simone,Brogi ^[2] ; Kyoji,Urayama ^[1] ; Toshishide,Nishi ^[3] ; Hitoshi,Kurose ^[4] ; Andrea,Tafi ^[5] ; Nigel,Ribeiro ^[6] ; Laurent,Désaubry ^[6] ; Canan G,Nebigil ^[1]

作者单位： Biotechnology and Cell Signaling Laboratory (UMR 7242), CNRS-University of Strasbourg, Illkirch, France. ^[1] European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Siena, Italy; Departments of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy. ^[2] Biotechnology and Cell Signaling Laboratory (UMR 7242), CNRS-University of Strasbourg, Illkirch, France; Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. ^[3] Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan. ^[4] Departments of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy. ^[5] Therapeutic Innovation Laboratory (UMR7200), CNRS-University of Strasbourg, Illkirch, France. ^[6]

主题词动物(Animals);苯甲酰胺类(Benzamides);结合部位(Binding Sites);血压(Blood Pressure);CHO细胞(CHO Cells);钙(Calcium);细胞, 培养的(Cells, Cultured);计算生物学(Computational Biology);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);疾病模型, 动物(Disease Models, Animal);超声心动描记术(Echocardiography);内皮细胞(Endothelial Cells);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);显微镜检查, 共焦(Microscopy, Confocal);心肌梗死(Myocardial Infarction);肽类(Peptides);预防和防护用药(Protective Agents);吡啶类(Pyridines);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);信号传导(Signal Transduction)

DOI 10.1371/journal.pone.0121027

PMID 25831128

发布时间 2024-03-26

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Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1.

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Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1.

PloS one

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PloS one

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