Continuous twin screw melt granulation of glyceryl behenate: Development of controlled release tramadol hydrochloride tablets for improved safety.
第一作者:
Justin M,Keen
第一单位:
The University of Texas at Austin, 1 University Station, Austin, TX 78712, USA; DisperSol Technologies, 111 W. Cooperative Way, Suite 200, Georgetown, TX 78626, USA. Electronic address: jmkeen@utexas.edu.
作者:
主题词
镇痛药, 阿片类(Analgesics, Opioid);迟效制剂(Delayed-Action Preparations);药物调剂(Drug Compounding);药物稳定性(Drug Stability);辅药(Excipients);脂肪酸类(Fatty Acids);粒子大小(Particle Size);粉剂(Powders);溶解度(Solubility);片剂(Tablets);曲马朵(Tramadol)
DOI
10.1016/j.ijpharm.2015.03.058
PMID
25839417
发布时间
2015-05-13
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