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Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms.

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第一作者: William,Tapper
第一单位: 1] Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK [2] Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury SP2 8BJ, UK.
作者单位: 1] Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK [2] Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury SP2 8BJ, UK. [1] CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna 1090, Austria. [2] Haematology Research Laboratory, Biomedical Research Foundation, Academy of Athens, Athens 11527, Greece. [3] 1] Department of Haematology, Addenbrooke's Hospital, Cambridge CB2 0XY, UK [2] Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK. [4] Laboratorio Congiunto MMPC, Department of Experimental and Clinical Medicine, University of Florence, Florence 50134, Italy. [5] Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury SP2 8BJ, UK. [6] Haematological Malignancy Diagnostic Service, St James's Institute of Oncology, Bexley Wing, St James's University Hospital, Leeds LS9 7TF, UK. [7] Department of Haematology, Royal Bournemouth Hospital, Bournemouth BH7 7DW, UK. [8] Department of Haematology, University Hospital Southampton, Southampton SO16 6YD, UK. [9] Oxford Biomedical Research Centre, Molecular Diagnostic Laboratory, Oxford University Hospitals NHS Trust, Oxford OX3 7LE, UK. [10] Haematopoietic Stem Cell Biology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK. [11] 1] School of Cancer Sciences, University of Birmingham,, Birmingham B15 2TT, UK [2] West Midlands Regional Genetics Laboratory, Birmingham Women's NHS Foundation Trust, Birmingham B15 2TG, UK. [12] Birmingham Heartlands Hospital, Birmingham B9 5SS, UK. [13] Department of Haematology, UCL Cancer Institute, London WC1 E6BT, UK. [14] MLL Munich Leukaemia Laboratory, Munich 81377, Germany. [15] Department of Internal Medicine III, University Hospital of Ulm, Ulm 89081, Germany. [16] 1] Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany [2] German Center for Diabetes Research, Neuherberg 85764, Germany. [17] 1] Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany [2] Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 80539 Munich, Germany. [18] Longitudinal Study Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21224-6825, USA. [19] Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence 50122, Italy. [20] Medical University of Vienna, Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Vienna 1090, Austria. [21] Center for the Study of Myelofibrosis, IRCCS Policlinico San Matteo Foundation, Pavia 27100, Italy. [22] 1] Department of Molecular Medicine, University of Pavia, Pavia, Italy [2] Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia 27100, Italy. [23] III. Medizinische Klinik, Universitätsmedizin Mannheim, Mannheim 68167, Germany. [24] Department of Haematology, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, London SE1 9RT, UK. [25] Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. [26]
DOI 10.1038/ncomms7691
PMID 25849990
发布时间 2025-05-29
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