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MDM2 antagonist clinical response association with a gene expression signature in acute myeloid leukaemia.

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第一作者： Hua,Zhong

第一单位： Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA. hua.zhong@roche.com.

作者： Hua,Zhong ^[1] ; Gong,Chen ^[2] ; Lori,Jukofsky ^[3] ; David,Geho ^[3] ; Sung Won,Han ^[4] ; Fabian,Birzele ^[5] ; Sabine,Bader ^[5] ; Lucia,Himmelein ^[5] ; James,Cai ^[6] ; Zayed,Albertyn ^[6] ; Mark,Rothe ^[7] ; Laurent,Essioux ^[8] ; Helmut,Burtscher ^[9] ; Steven A,Middleton ^[3] ; Ruediger,Rueger ^[10] ; Lin-Chi,Chen ^[3] ; Markus,Dangl ^[9] ; Gwen,Nichols ^[3] ; William E,Pierceall ^[3]

作者单位： Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA. hua.zhong@roche.com. ^[1] Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA. ^[2] Translational Medicine Oncology, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA. ^[3] Division of Biostatistics, Departments of Population Health, New York University School of Medicine, New York, NY, USA. ^[4] Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Penzberg, Penzberg, Germany. ^[5] Informatics, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA. ^[6] Biometrics, Product Development, Roche Innovation Center New York, New York, NY, USA. ^[7] Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland. ^[8] Discovery Oncology, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Penzberg, Penzberg, Germany. ^[9] Translational Medicine Oncology, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Penzberg, Penzberg, Germany. ^[10]

关键词 MDM2 antagonist TP53 acute myeloid leukaemia diagnostic algorithm gene expression signature