Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.-论文-万方医学网

作者： Sang-Uk,Seo ^[1] ; Nobuhiko,Kamada ^[2] ; Raúl,Muñoz-Planillo ^[1] ; Yun-Gi,Kim ^[1] ; Donghyun,Kim ^[1] ; Yukiko,Koizumi ^[1] ; Mizuho,Hasegawa ^[1] ; Stephanie D,Himpsl ^[3] ; Hilary P,Browne ^[4] ; Trevor D,Lawley ^[4] ; Harry L T,Mobley ^[3] ; Naohiro,Inohara ^[1] ; Gabriel,Núñez ^[5]

作者单位： Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. ^[1] Division of Gastroenterology, Department of Internal Medicine, The University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. ^[2] Department of Microbiology and Immunology, The University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. ^[3] Bacterial Pathogenesis Laboratory, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. ^[4] Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: gabriel.nunez@umich.edu. ^[5]

主题词动物(Animals);抗原, Ly(Antigens, Ly);载体蛋白质类(Carrier Proteins);基因表达调控(Gene Expression Regulation);溶血素蛋白质类(Hemolysin Proteins);炎性体(Inflammasomes);炎症(Inflammation);白细胞介素1β(Interleukin-1beta);肠(Intestines);巨噬细胞(Macrophages);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);单核细胞(Monocytes);变形杆菌感染(Proteus Infections);奇异变形杆菌(Proteus mirabilis);受体, CCR2(Receptors, CCR2);沙门菌属(Salmonella);沙门菌感染(Salmonella Infections);信号传导(Signal Transduction);共生(Symbiosis)

DOI 10.1016/j.immuni.2015.03.004

PMID 25862092

发布时间 2024-06-10

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Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.

Immunity

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Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.

Immunity

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Immunity

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