首页> Cancer science> Aspartate-modified doxorubicin on its N-terminal increases drug accumulation in LAT1-overexpressing tumors.

Aspartate-modified doxorubicin on its N-terminal increases drug accumulation in LAT1-overexpressing tumors.

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第一作者： Weidang,Wu

第一单位： School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.;State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China.

作者： Weidang,Wu ^[1] ; Yan,Dong ^[2] ; Jing,Gao ^[3] ; Min,Gong ^[3] ; Xing,Zhang ^[4] ; Weiling,Kong ^[3] ; Yazhuo,Li ^[3] ; Yong,Zeng ^[3] ; Duanyun,Si ^[3] ; Zihong,Wei ^[3] ; Xiaoyan,Ci ^[3] ; Lixin,Jiang ^[5] ; Wei,Li ^[3] ; Quansheng,Li ^[3] ; Xiulin,Yi ^[3] ; Changxiao,Liu ^[6]

作者单位： School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.;State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China. ^[1] State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China.;Tianjin Medical University, Tianjin, China. ^[2] State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China. ^[3] Tianjin University of Traditional Chinese Medicine, Tianjin, China. ^[4] Hefei Tianmai Biotechnology Development Co., Ltd, Hefei, China. ^[5] School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.;State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, China.;Tianjin University of Traditional Chinese Medicine, Tianjin, China. ^[6]

关键词 Anticancer drugs Asp-DOX HepG2 LAT1 P-glycoprotein