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Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats.

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第一作者： A,Jabs

第一单位： 2nd Medical Clinic, Department of Cardiology, Medical Center of the Johannes Gutenberg University, Mainz, Germany.

作者： A,Jabs ^[1] ; M,Oelze ^[1] ; Y,Mikhed ^[1] ; P,Stamm ^[1] ; S,Kröller-Schön ^[1] ; P,Welschof ^[1] ; T,Jansen ^[1] ; M,Hausding ^[1] ; M,Kopp ^[1] ; S,Steven ^[1] ; E,Schulz ^[1] ; J-P,Stasch ^[2] ; T,Münzel ^[1] ; A,Daiber ^[3]

作者单位： 2nd Medical Clinic, Department of Cardiology, Medical Center of the Johannes Gutenberg University, Mainz, Germany. ^[1] Bayer Pharma AG, Wuppertal, Germany. ^[2] 2nd Medical Clinic, Department of Cardiology, Medical Center of the Johannes Gutenberg University, Mainz, Germany. Electronic address: daiber@uni-mainz.de. ^[3]

关键词 3-nitrotyrosine (PubChem CID: 65124)Endothelial dysfunction L-012 (PubChem CID: 126741)Nitroglycerin tolerance Oxidative stress dihydroethidium (PubChem CID: 128682)nitric oxide (PubChem CID: 145068)nitroglycerin (PubChem CID: 4510)peroxynitrite (PubChem CID: 104806)sGC activator sGC stimulator sGC stimulator BAY 41-8543 (PubChem CID: 9953906)superoxide (PubChem CID: 5359597)