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首页> European journal of medicinal chemistry> Design, synthesis, biological evaluation and preliminary mechanism study of novel benzothiazole derivatives bearing indole-based moiety as potent antitumor agents.

Design, synthesis, biological evaluation and preliminary mechanism study of novel benzothiazole derivatives bearing indole-based moiety as potent antitumor agents.

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作者： Junjie,Ma ^[1] ; Guanglong,Bao ^[1] ; Limei,Wang ^[1] ; Wanting,Li ^[1] ; Boxuan,Xu ^[1] ; Baoquan,Du ^[1] ; Jie,Lv ^[1] ; Xin,Zhai ^[2] ; Ping,Gong ^[3]

作者单位： Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, 103 Wenhua Road, Shenhe District, 110016, PR China. ^[1] Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, 103 Wenhua Road, Shenhe District, 110016, PR China. Electronic address: leixinjia@126.com. ^[2] Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, 103 Wenhua Road, Shenhe District, 110016, PR China. Electronic address: gongpinggp@126.com. ^[3]

关键词 3D-QSAR Antitumor activity Benzothiazole Indole-based moiety Synthesis

主题词抗肿瘤药(Antineoplastic Agents);苯并噻唑类(Benzothiazoles);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物设计(Drug Design);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);人类(Humans);吲哚类(Indoles);模型, 分子(Models, Molecular);分子结构(Molecular Structure);量化构效关系(Quantitative Structure-Activity Relationship)

DOI 10.1016/j.ejmech.2015.04.018

PMID 25874341

发布时间 2015-05-18

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European journal of medicinal chemistry

173-86页

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