Design, synthesis, biological evaluation and preliminary mechanism study of novel benzothiazole derivatives bearing indole-based moiety as potent antitumor agents.
第一作者:
Junjie,Ma
第一单位:
Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, 103 Wenhua Road, Shenhe District, 110016, PR China.
作者:
医学主题词
抗肿瘤药(Antineoplastic Agents);苯并噻唑类(Benzothiazoles);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物设计(Drug Design);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);人类(Humans);吲哚类(Indoles);模型, 分子(Models, Molecular);分子结构(Molecular Structure);量化构效关系(Quantitative Structure-Activity Relationship)
DOI
10.1016/j.ejmech.2015.04.018
PMID
25874341
发布时间
2015-05-18
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