Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I.

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作者： Nisha,Yadav ^[1] ; Taran,Khanam ; Ankita,Shukla ; Niyati,Rai ; Kanchan,Hajela ; Ravishankar,Ramachandran

作者单位： From Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sector10, Jankipuram Extension, Sitapur Road, Uttar Pradesh, Lucknow-226031, India. kanchan_hajela@cdri.res.in. ^[1]

主题词抗菌药(Anti-Bacterial Agents);细菌(Bacteria);DNA(DNA);DNA连接酶类(DNA Ligases);二苯氧氮|艹卓|类(Dibenzoxazepines);酶测定(Enzyme Assays);酶抑制剂(Enzyme Inhibitors);大肠杆菌(Escherichia coli);人类(Humans);吲哚类(Indoles);微生物敏感性试验(Microbial Sensitivity Tests);结核分枝杆菌(Mycobacterium tuberculosis);鼠伤寒沙门菌(Salmonella typhimurium)

DOI 10.1039/c5ob00439j

PMID 25875403

发布时间 2016-11-25

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Organic & biomolecular chemistry

2015年13卷19期

5475-87页

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Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I.

Organic & biomolecular chemistry

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Organic & biomolecular chemistry

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Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I.

Organic & biomolecular chemistry

相似文献

Organic & biomolecular chemistry

相关期刊

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