Activation of Flucloxacillin-Specific CD8+ T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model.

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作者： Ryan,Nattrass ^[1] ; Lee,Faulkner ^[1] ; Marc,Vocanson ^[2] ; Daniel J,Antoine ^[1] ; Anja,Kipar ^[3] ; Gerry,Kenna ^[4] ; Jean-Francois,Nicolas ^[2] ; B Kevin,Park ^[1] ; Dean J,Naisbitt ^[5]

作者单位： *Department of Pharmacology, MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool L69 3GE, UK. ^[1] International Center for Infectiology Research, Inserm, U1111, University of Lyon 1 69007, Lyon, France. ^[2] *Department of Pharmacology, MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool L69 3GE, UK, AstraZeneca R&D, Alderley Park, Macclesfield SK10 4TF, UK and. ^[3] Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, 268 8057 Zurich, Switzerland. ^[4] *Department of Pharmacology, MRC Centre for Drug Safety Science, The University of Liverpool, Liverpool L69 3GE, UK, dnes@liv.ac.uk. ^[5]

关键词 flucloxacillin immunogenicity liver injury

主题词动物(Animals);抗菌药(Anti-Bacterial Agents);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);氟氯西林(Floxacillin);肝细胞(Hepatocytes);小鼠(Mice)

DOI 10.1093/toxsci/kfv077

PMID 25877613

发布时间 2022-01-29

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