Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation.
第一作者:
Malte P,Bartram
第一单位:
Department II of Internal Medicine and Center for Molecular Medicine, University of Cologne, Kerpener Str. 62, Cologne, 50937, Germany. malte.bartram@uk-koeln.de.
作者:
医学主题词
动物(Animals);基因表达调控, 发育期(Gene Expression Regulation, Developmental);基因敲除技术(Gene Knockout Techniques);肾盂积水(Hydronephrosis);整合酶类(Integrases);肾(Kidney);肾疾病, 囊性(Kidney Diseases, Cystic);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);微RNAs(MicroRNAs);肾单位(Nephrons);表型(Phenotype);RNA结合蛋白质类(RNA-Binding Proteins);肾功能不全(Renal Insufficiency);核糖核酸酶Ⅲ(Ribonuclease III);泌尿生殖系统畸形(Urogenital Abnormalities)
DOI
10.1186/s12882-015-0053-1
PMID
25881298
发布时间
2018-11-13
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