Determination of co-administrated opioids and benzodiazepines in urine using column-switching solid-phase extraction and liquid chromatography-tandem mass spectrometry.

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作者： Lingjuan,Xiong ^[1] ; Rong,Wang ^[2] ; Chen,Liang ^[2] ; Xiaomei,Teng ^[3] ; Fengli,Jiang ^[4] ; Libo,Zeng ^[2] ; Haiying,Ye ^[2] ; Chunfang,Ni ^[2] ; Xiaoliang,Yuan ^[2] ; Yulan,Rao ^[5] ; Yurong,Zhang ^[6]

作者单位： Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Institute of Forensic Science, Shanghai, PR China; State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai, PR China; Pharmacy Department of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, PR China. ^[1] Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Institute of Forensic Science, Shanghai, PR China. ^[2] Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Institute of Forensic Science, Shanghai, PR China; State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai, PR China. ^[3] Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Institute of Forensic Science, Shanghai, PR China; Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, PR China. ^[4] Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, PR China. Electronic address: yulan_rao@fudan.edu.cn. ^[5] Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Institute of Forensic Science, Shanghai, PR China. Electronic address: yr_zhang@126.com. ^[6]

关键词 Benzodiazepines Co-administration Column-switching solid-phase extraction Glucuronide metabolites Opioids Urine