换一批The criticality of high-resolution N-linked carbohydrate assays and detailed characterization of antibody effector function in the context of biosimilar development.
第一作者：
Lowell J,Brady
第一单位：
a Physical Chemistry Characterization; Sandoz Biopharmaceuticals ; Oberhaching , Germany.
作者：
关键词
ACN, acetonitrileADCCADCC, antibody-dependent cell-mediated cytotoxicityAHGs, afucosylated hybrid glycansAMBGs, afucosylated monoantennary and biantennary glycansBGGs, β-galactosylated glycansCDCCDC, complement-dependent cytotoxicityCHO, Chinese hamster ovaryCQA, critical quality attributeCon A, concanavalin A lectinEIC, extracted ion currentFT, flow-throughFc domainHC, heavy chainHGs, hybrid glycansHILIC, hydrophilic interaction liquid chromatographyHMGs, high-mannose glycansHPLC, high performance liquid chromatographyLC, light chainMS, mass spectrometryMS/MS, tandem mass spectrometryN-linked carbohydratesPQA, product quality attributeSGs, sialylated glycansSM, starting materialTRIS, tris(hydroxymethyl)aminomethaneantibodybiosimilareffector functionglycosylationmAbmAb, monoclonal antibody
医学主题词
抗体, 单克隆(Antibodies, Monoclonal);抗体依赖细胞细胞毒性(Antibody-Dependent Cell Cytotoxicity);生物学鉴定法(Biological Assay);细胞系(Cell Line);人类(Humans);免疫球蛋白Fc片段(Immunoglobulin Fc Fragments);免疫球蛋白G(Immunoglobulin G);多糖类(Polysaccharides)
DOI
10.1080/19420862.2015.1016692
PMID
25898160
发布时间
2022-03-30
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