Decreased DNA methylation in the promoter region of the WNT5A and GDNF genes may promote the osteogenicity of mesenchymal stem cells from patients with ossified spinal ligaments.
第一作者:
Noriyuki,Chiba
第一单位:
Department of Pharmacology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan; Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan.
作者:
主题词
老年人(Aged);老年人, 80以上(Aged, 80 and over);细胞, 培养的(Cells, Cultured);DNA甲基化(DNA Methylation);女(雌)性(Female);胶质细胞源性神经营养因子(Glial Cell Line-Derived Neurotrophic Factor);人类(Humans);韧带(Ligaments);男(雄)性(Male);间质干细胞(Mesenchymal Stem Cells);中年人(Middle Aged);后纵韧带骨化(Ossification of Posterior Longitudinal Ligament);骨化, 异位性(Ossification, Heterotopic);启动区, 遗传(Promoter Regions, Genetic);原癌基因蛋白质类(Proto-Oncogene Proteins);脊柱(Spine);组织阵列分析(Tissue Array Analysis);Wnt蛋白质类(Wnt Proteins)
DOI
10.1016/j.jphs.2015.03.008
PMID
25913759
发布时间
2022-03-18
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