Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling.

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第一作者： Yong Ryoul,Yang

第一单位： School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.

作者： Yong Ryoul,Yang ^[1] ; Dae Hyun,Kim ^[1] ; Young-Kyo,Seo ^[1] ; Dohyun,Park ^[2] ; Hyun-Jun,Jang ^[3] ; Soo Youn,Choi ^[1] ; Yong Hwa,Lee ^[1] ; Gyun Hui,Lee ^[1] ; Kazuki,Nakajima ^[4] ; Naoyuki,Taniguchi ^[4] ; Jung-Min,Kim ^[1] ; Eun-Jeong,Choi ^[2] ; Hyo Youl,Moon ^[1] ; Il Shin,Kim ^[1] ; Jang Hyun,Choi ^[1] ; Ho,Lee ^[5] ; Sung Ho,Ryu ^[2] ; Lucio,Cocco ^[6] ; Pann-Ghill,Suh ^[1]

作者单位： School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea. ^[1] Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea. ^[2] School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.;Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea. ^[3] Disease Glycomics Team, Systems Glycobiology Research Group, RIKENMax Planck Joint Research Center, Global Research Cluster, RIKEN, Hirosawa, Wako, Saitama, Japan. ^[4] Cancer Experimental Resources Branch, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea. ^[5] Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. ^[6]

关键词 O-GlcNAcase O-GlcNAcylation colitis colitis-associated cancer