Translational toxicology in setting occupational exposure limits for dusts and hazard classification - a critical evaluation of a recent approach to translate dust overload findings from rats to humans.

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第一作者： Peter,Morfeld

第一单位： Institute for Occupational Epidemiology and Risk Assessment of Evonik Industries, AG Rellinghauser Straße 1-11, Essen, 45128, Germany. peter.morfeld@evonik.com.

作者： Peter,Morfeld ^[1] ; Joachim,Bruch ^[2] ; Len,Levy ^[3] ; Yufanyi,Ngiewih ^[4] ; Ishrat,Chaudhuri ^[5] ; Henry J,Muranko ^[6] ; Ross,Myerson ^[7] ; Robert J,McCunney ^[8]

作者单位： Institute for Occupational Epidemiology and Risk Assessment of Evonik Industries, AG Rellinghauser Straße 1-11, Essen, 45128, Germany. peter.morfeld@evonik.com. ^[1] Institute and Policlinic for Occupational Medicine, Environmental Medicine and Preventive Research, University of Cologne, Cologne, Germany. peter.morfeld@evonik.com. ^[2] University Duisburg-Essen, Medical Faculty, Essen, Germany. joachim.bruch@ibe-marl.de. ^[3] IBE GmbH, Cologne, Germany. joachim.bruch@ibe-marl.de. ^[4] Cranfield University, ᅟ, Cranfield, UK. len.levy@cranfield.ac.uk. ^[5] Orion Engineered Carbons GmbH, ᅟ, Cologne, Germany. yufanyi.ngiewih@orioncarbons.com. ^[6] Cabot Corporation, Billerica, MA, USA. ishrat_chaudhuri@cabot-corp.com. ^[7] Muranko & Associates, Scottsdale, AZ, USA. hank.muranko@cox.net. ^[8] Department of Occupational Health, MedStar Washington Hospital Center, Washington, DC, USA. rsmyerson@verizon.net. ^[9] The George Washington University School of Public Health, Washington, DC, USA. rsmyerson@verizon.net. ^[10] Massachusetts Institute of Technology, Cambridge, MA, USA. mccunney@mit.edu. ^[11] Brigham and Women's Hospital, Boston, MA, USA. mccunney@mit.edu. ^[12]

主题词空气污染物, 职业性(Air Pollutants, Occupational);动物(Animals);支气管肺泡灌洗液(Bronchoalveolar Lavage Fluid);致癌性试验(Carcinogenicity Tests);粉尘(Dust);人类(Humans);插管法, 气管内(Intubation, Intratracheal);肺肿瘤(Lung Neoplasms);职业暴露(Occupational Exposure);试验预期值(Predictive Value of Tests);大鼠(Rats);结果可重复性(Reproducibility of Results);研究设计(Research Design);种特异性(Species Specificity);阈限值(Threshold Limit Values)

DOI 10.1186/s12989-015-0079-3

PMID 25925672

发布时间 2024-03-23

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Translational toxicology in setting occupational exposure limits for dusts and hazard classification - a critical evaluation of a recent approach to translate dust overload findings from rats to humans.

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Translational toxicology in setting occupational exposure limits for dusts and hazard classification - a critical evaluation of a recent approach to translate dust overload findings from rats to humans.

Particle and fibre toxicology

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Particle and fibre toxicology

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