换一批PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD).
第一作者：
Tamara,Ratovitski
第一单位：
a Division of Neurobiology; Department of Psychiatry; Johns Hopkins University School of Medicine ; CMSC 8-121; Baltimore , MD , USA.
作者：
关键词
BDNF, brain-derived neurotrophic factorCB, Cajal bodyChIP, the chromatin immunoprecipitationDMEM, Dulbecco's modified Eagle's mediumFBS, fetal bovine serumHD, Huntington's diseaseHEK, human embryonic kidneyHtt, huntingtinHuntington's disease mechanismIP, immunoprecipitationIgG, immunoglobulinPIC, protease inhibitors cocktailPRMT5, protein arginine methyltransferaseRNA processingSMN, survival of motor neuronsSm proteins, spleceosomal small nuclear ribonucleoproteinsgene transcriptionhuntingtinneurodegenerationpolyQ, polyglutamineprotein interactionsprotein methylationsDMA, symmetrical arginine dimethylationsnRNPs, small nuclear ribonucleoprotein particles
医学主题词
动物(Animals);精氨酸(Arginine);印迹法, 蛋白质(Blotting, Western);脑(Brain);后成说, 遗传(Epigenesis, Genetic);基因表达调控(Gene Expression Regulation);HEK293细胞(HEK293 Cells);人类(Humans);杭廷顿病(Huntington Disease);小鼠(Mice);显微镜检查, 荧光(Microscopy, Fluorescence);神经组织蛋白质类(Nerve Tissue Proteins);核蛋白质类(Nuclear Proteins);蛋白质精氨酸N-甲基转移酶(Protein-Arginine N-Methyltransferases);大鼠(Rats)
DOI
10.1080/15384101.2015.1033595
PMID
25927346
发布时间
2020-09-30
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Cell cycle (Georgetown, Tex.)
1716-29页
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