换一批
换一批An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions.
作者：
关键词
ADCC, antibody-dependent cell-mediated cytotoxicityADCP, antibody-dependent cellular phagocytosisADCR, antibody-dependent cytokine releaseAPCs, antigen-presenting cellsCDC, complement-dependent cytotoxicityDC, dendritic cellFc gamma receptorsFcγR, Fc gamma receptorIFN, interferonIL, interleukinNK, natural killerPBMC, peripheral blood mononuclear cellTNF, tumor necrosis factorantibody-dependent cellular phagocytosiscytokine releaseinterferon gammainterleukin 10mAbs, monoclonal antibodiesmonocyte-derived macrophagesnatural killer cells
主题词
抗体, 单克隆(Antibodies, Monoclonal);抗体, 肿瘤(Antibodies, Neoplasm);抗体依赖细胞细胞毒性(Antibody-Dependent Cell Cytotoxicity);细胞系, 肿瘤(Cell Line, Tumor);细胞因子类(Cytokines);人类(Humans);免疫球蛋白Fc片段(Immunoglobulin Fc Fragments);巨噬细胞(Macrophages);肿瘤(Neoplasms);蛋白质工程(Protein Engineering);肿瘤微环境(Tumor Microenvironment)
DOI
10.1080/19420862.2015.1022692
PMID
25933349
发布时间
2021-01-03
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