4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors.

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作者： Adrienne H,Long ^[1] ; Waleed M,Haso ^[2] ; Jack F,Shern ^[2] ; Kelsey M,Wanhainen ^[3] ; Meera,Murgai ^[2] ; Maria,Ingaramo ^[4] ; Jillian P,Smith ^[2] ; Alec J,Walker ^[2] ; M Eric,Kohler ^[5] ; Vikas R,Venkateshwara ^[2] ; Rosandra N,Kaplan ^[2] ; George H,Patterson ^[4] ; Terry J,Fry ^[2] ; Rimas J,Orentas ^[2] ; Crystal L,Mackall ^[2]

作者单位： 1] Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. ^[1] Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. ^[2] 1] Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Department of Biology, Colgate University, Hamilton, New York, USA. ^[3] Section on Biophotonics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA. ^[4] 1] Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Department of Pediatrics, Johns Hopkins Hospital, Baltimore, Maryland, USA. ^[5]