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A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer.

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第一作者： Dean A,Troyer

第一单位： Eastern Virginia Medical School, Pathology and Microbiology and Molecular Biology, Norfolk, Virginia.;Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.

作者： Dean A,Troyer ^[1] ; Tamara,Jamaspishvili ^[2] ; Wei,Wei ^[3] ; Ziding,Feng ^[3] ; Jennifer,Good ^[2] ; Sarah,Hawley ^[4] ; Ladan,Fazli ^[5] ; Jesse K,McKenney ^[6] ; Jeff,Simko ^[7] ; Antonio,Hurtado-Coll ^[5] ; Peter R,Carroll ^[8] ; Martin,Gleave ^[5] ; Raymond,Lance ^[9] ; Daniel W,Lin ^[10] ; Peter S,Nelson ^[11] ; Ian M,Thompson ^[12] ; Lawrence D,True ^[13] ; James D,Brooks ^[14] ; Jeremy A,Squire ^[15]

作者单位： Eastern Virginia Medical School, Pathology and Microbiology and Molecular Biology, Norfolk, Virginia.;Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas. ^[1] Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada. ^[2] Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas. ^[3] Canary Foundation, Canary Center at Stanford, 3155 Porter Drive, Palo Alto. ^[4] The Prostate Center at Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada. ^[5] Department of Pathology, Cleveland Clinic, Cleveland, Ohio. ^[6] Department of Pathology, University of California San Francisco, San Francisco, California.;Department of Urology, University of California San Francisco, San Francisco, California. ^[7] Department of Urology, University of California San Francisco, San Francisco, California. ^[8] Department of Urology, Eastern Virginia Medical School, Norfolk, Virginia. ^[9] Department of Urology, University of Washington, Seattle, Washington. ^[10] Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington. ^[11] Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas. ^[12] Department of Pathology, University of Washington Medical Center, Seattle, Washington. ^[13] Department of Urology, Stanford University, Stanford, California. ^[14] Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.;Department of Pathology and Forensic Medicine, University of São Paulo at Ribeirão Preto, Brazil. ^[15]

关键词 Gleason score PI3K/PTEN/Akt pathway active surveillance biomarker fluorescence in situ hybridization tissue array analysis