MEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma.

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作者： Li Ren,Kong ^[1] ; Kian Ngiap,Chua ^[1] ; Wen Jing,Sim ^[2] ; Hsien Chun,Ng ^[2] ; Chonglei,Bi ^[1] ; Jingshan,Ho ^[3] ; Min En,Nga ^[4] ; Yin Huei,Pang ^[4] ; Weijie Richard,Ong ^[5] ; Ross Andrew,Soo ^[6] ; Hung,Huynh ^[5] ; Wee Joo,Chng ^[6] ; Jean-Paul,Thiery ^[7] ; Boon Cher,Goh ^[8]

作者单位： Cancer Science Institute of Singapore, National University of Singapore, Singapore. ^[1] Institute of Molecular and Cell Biology, A*STAR, Singapore. ^[2] Department of Hematology-Oncology, National University Hospital, Singapore. National University Cancer Institute, Singapore. ^[3] Department of Pathology, National University Hospital, Singapore. ^[4] National Cancer Centre, Singapore. ^[5] Cancer Science Institute of Singapore, National University of Singapore, Singapore. Department of Hematology-Oncology, National University Hospital, Singapore. National University Cancer Institute, Singapore. ^[6] Cancer Science Institute of Singapore, National University of Singapore, Singapore. Institute of Molecular and Cell Biology, A*STAR, Singapore. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. ^[7] Cancer Science Institute of Singapore, National University of Singapore, Singapore. Department of Hematology-Oncology, National University Hospital, Singapore. National University Cancer Institute, Singapore. phcgbc@nus.edu.sg. ^[8]