Local treatment of a pleural mesothelioma tumor with ONCOS-102 induces a systemic antitumor CD8<sup>+</sup> T-cell response, prominent infiltration of CD8<sup>+</sup> lymphocytes and Th1 type polarization.
第一作者:
Tuuli,Ranki
第一单位:
Oncos Therapeutics ; Helsinki, Finland.
作者:
关键词
APC, antigen presenting cellAdenovirusCCL2, (C-Cmotif) ligand 2CTCAE, common terminology criteria for adverse eventsCX3CL1, (C-X3-C motif) ligand 1CXCL10, (C-X-C motif) ligand 10CXCL9, (C-X-C motif) ligand 9ELISPOT, enzyme-linked immunospot assayGM-CSFGM-CSF, granulocyte macrophage colony stimulating factorIFNg, interferon gammaIRF1, interferon regulatory factor 1PET, positron emission tomographyRANTES, regulated on activation, normal T cell expressed and secretedTILs, tumor infiltrating lymphocytesTh1 polarizationVP, viral particleantitumor immunitycytotoxic immunotherapytumor infiltrating lymphocytes
DOI
10.4161/21624011.2014.958937
PMID
25941579
发布时间
2021-02-11
- 浏览64
Oncoimmunology
e958937页
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